Histological Changes in Autoimmune Hepatitis with Graves' Disease: A Child Case Report

We herein report a child case of autoimmune hepatitis (AIH) accompanied with Graves' disease. Elevated aminotransferase levels were found in a 12-year-old Japanese girl with Graves' disease. In her first liver biopsy, necrosis and inflammation was limited to the centrilobular area, while t...

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Detalles Bibliográficos
Autores principales: Yamada, Mamiko, Shibata, Hironori, Masugi, Yohei, Ishi, Tomohiro, Kameyama, Kaori, Ebinuma, Hirotoshi, Hasegawa, Tomonobu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Internal Medicine 2017
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5596273/
https://www.ncbi.nlm.nih.gov/pubmed/28781316
http://dx.doi.org/10.2169/internalmedicine.8417-16
Descripción
Sumario:We herein report a child case of autoimmune hepatitis (AIH) accompanied with Graves' disease. Elevated aminotransferase levels were found in a 12-year-old Japanese girl with Graves' disease. In her first liver biopsy, necrosis and inflammation was limited to the centrilobular area, while the second biopsy showed different findings. Namely, portal injury newly appeared, including interface hepatitis, which represents the histological characteristics of AIH. As the histological findings at the onset of AIH do not always show typical findings, a re-biopsy is considered to be important in individuals suspected to have AIH. AIH should be included in the differential diagnosis of liver dysfunction in Graves' disease, even in children.

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