Successful Treatment of TAFRO Syndrome with Tocilizumab, Prednisone, and Cyclophosphamide

TAFRO syndrome is a rare systemic inflammatory disease characterized by thrombocytopenia, pleural effusion, fever, renal dysfunction, reticulin fibrosis of the bone marrow, and organomegaly. The clinical course varies significantly among patients. However, the prognosis is usually dismal in patients...

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Detalles Bibliográficos
Autores principales: Kikuchi, Taku, Shimizu, Takayuki, Toyama, Takaaki, Abe, Ryohei, Okamoto, Shinichiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Internal Medicine 2017
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5596285/
https://www.ncbi.nlm.nih.gov/pubmed/28781319
http://dx.doi.org/10.2169/internalmedicine.8522-16
Descripción
Sumario:TAFRO syndrome is a rare systemic inflammatory disease characterized by thrombocytopenia, pleural effusion, fever, renal dysfunction, reticulin fibrosis of the bone marrow, and organomegaly. The clinical course varies significantly among patients. However, the prognosis is usually dismal in patients with severe TAFRO syndrome, and no optimal treatment has yet been established. We herein describe the first case of TAFRO syndrome, which was successfully treated with combination therapy consisting of tocilizumab, prednisone, and cyclophosphamide.

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