Successful Treatment of TAFRO Syndrome with Tocilizumab, Prednisone, and Cyclophosphamide

TAFRO syndrome is a rare systemic inflammatory disease characterized by thrombocytopenia, pleural effusion, fever, renal dysfunction, reticulin fibrosis of the bone marrow, and organomegaly. The clinical course varies significantly among patients. However, the prognosis is usually dismal in patients...

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Autores principales: Kikuchi, Taku, Shimizu, Takayuki, Toyama, Takaaki, Abe, Ryohei, Okamoto, Shinichiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Internal Medicine 2017
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5596285/
https://www.ncbi.nlm.nih.gov/pubmed/28781319
http://dx.doi.org/10.2169/internalmedicine.8522-16
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author Kikuchi, Taku
Shimizu, Takayuki
Toyama, Takaaki
Abe, Ryohei
Okamoto, Shinichiro
author_facet Kikuchi, Taku
Shimizu, Takayuki
Toyama, Takaaki
Abe, Ryohei
Okamoto, Shinichiro
author_sort Kikuchi, Taku
collection PubMed
description TAFRO syndrome is a rare systemic inflammatory disease characterized by thrombocytopenia, pleural effusion, fever, renal dysfunction, reticulin fibrosis of the bone marrow, and organomegaly. The clinical course varies significantly among patients. However, the prognosis is usually dismal in patients with severe TAFRO syndrome, and no optimal treatment has yet been established. We herein describe the first case of TAFRO syndrome, which was successfully treated with combination therapy consisting of tocilizumab, prednisone, and cyclophosphamide.
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spelling pubmed-55962852017-09-14 Successful Treatment of TAFRO Syndrome with Tocilizumab, Prednisone, and Cyclophosphamide Kikuchi, Taku Shimizu, Takayuki Toyama, Takaaki Abe, Ryohei Okamoto, Shinichiro Intern Med Case Report TAFRO syndrome is a rare systemic inflammatory disease characterized by thrombocytopenia, pleural effusion, fever, renal dysfunction, reticulin fibrosis of the bone marrow, and organomegaly. The clinical course varies significantly among patients. However, the prognosis is usually dismal in patients with severe TAFRO syndrome, and no optimal treatment has yet been established. We herein describe the first case of TAFRO syndrome, which was successfully treated with combination therapy consisting of tocilizumab, prednisone, and cyclophosphamide. The Japanese Society of Internal Medicine 2017-08-01 2017-08-15 /pmc/articles/PMC5596285/ /pubmed/28781319 http://dx.doi.org/10.2169/internalmedicine.8522-16 Text en Copyright © 2017 by The Japanese Society of Internal Medicine https://creativecommons.org/licenses/by-nc-nd/4.0/ The Internal Medicine is an Open Access article distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. To view the details of this license, please visit (https://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Case Report
Kikuchi, Taku
Shimizu, Takayuki
Toyama, Takaaki
Abe, Ryohei
Okamoto, Shinichiro
Successful Treatment of TAFRO Syndrome with Tocilizumab, Prednisone, and Cyclophosphamide
title Successful Treatment of TAFRO Syndrome with Tocilizumab, Prednisone, and Cyclophosphamide
title_full Successful Treatment of TAFRO Syndrome with Tocilizumab, Prednisone, and Cyclophosphamide
title_fullStr Successful Treatment of TAFRO Syndrome with Tocilizumab, Prednisone, and Cyclophosphamide
title_full_unstemmed Successful Treatment of TAFRO Syndrome with Tocilizumab, Prednisone, and Cyclophosphamide
title_short Successful Treatment of TAFRO Syndrome with Tocilizumab, Prednisone, and Cyclophosphamide
title_sort successful treatment of tafro syndrome with tocilizumab, prednisone, and cyclophosphamide
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5596285/
https://www.ncbi.nlm.nih.gov/pubmed/28781319
http://dx.doi.org/10.2169/internalmedicine.8522-16
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AT aberyohei successfultreatmentoftafrosyndromewithtocilizumabprednisoneandcyclophosphamide
AT okamotoshinichiro successfultreatmentoftafrosyndromewithtocilizumabprednisoneandcyclophosphamide

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