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Value of combining dynamic contrast enhanced ultrasound and optoacoustic tomography for hypoxia imaging

Optoacoustic imaging (OAI) can detect haemoglobin and assess its oxygenation. However, the lack of a haemoglobin signal need not indicate a lack of perfusion. This study uses a novel method to assist the co-registration of optoacoustic images with dynamic contrast enhanced ultrasound (DCE-US) images...

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Detalles Bibliográficos
Autores principales: Shah, Anant, Bush, Nigel, Box, Gary, Eccles, Suzanne, Bamber, Jeffrey
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5596361/
https://www.ncbi.nlm.nih.gov/pubmed/28932684
http://dx.doi.org/10.1016/j.pacs.2017.08.001
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author Shah, Anant
Bush, Nigel
Box, Gary
Eccles, Suzanne
Bamber, Jeffrey
author_facet Shah, Anant
Bush, Nigel
Box, Gary
Eccles, Suzanne
Bamber, Jeffrey
author_sort Shah, Anant
collection PubMed
description Optoacoustic imaging (OAI) can detect haemoglobin and assess its oxygenation. However, the lack of a haemoglobin signal need not indicate a lack of perfusion. This study uses a novel method to assist the co-registration of optoacoustic images with dynamic contrast enhanced ultrasound (DCE-US) images to demonstrate, in preclinical tumour models, the value of combining haemoglobin imaging with a perfusion imaging method, showing that a lack of a haemoglobin signal does not necessarily indicate an absence of perfusion. DCE-US was chosen for this particular experiment because US is extremely sensitive to microbubble contrast agents and because microbubbles, like red blood cells but unlike currently available optical contrast agents, do not extravasate. Significant spatial correlations were revealed between the DCE-US properties and tumour blood-oxygen saturation and haemoglobin, as estimated using OAI. It is speculated that DCE-US properties could be applied as surrogate biomarkers for hypoxia when planning clinical radiotherapy or chemotherapy.
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spelling pubmed-55963612017-09-20 Value of combining dynamic contrast enhanced ultrasound and optoacoustic tomography for hypoxia imaging Shah, Anant Bush, Nigel Box, Gary Eccles, Suzanne Bamber, Jeffrey Photoacoustics Research Article Optoacoustic imaging (OAI) can detect haemoglobin and assess its oxygenation. However, the lack of a haemoglobin signal need not indicate a lack of perfusion. This study uses a novel method to assist the co-registration of optoacoustic images with dynamic contrast enhanced ultrasound (DCE-US) images to demonstrate, in preclinical tumour models, the value of combining haemoglobin imaging with a perfusion imaging method, showing that a lack of a haemoglobin signal does not necessarily indicate an absence of perfusion. DCE-US was chosen for this particular experiment because US is extremely sensitive to microbubble contrast agents and because microbubbles, like red blood cells but unlike currently available optical contrast agents, do not extravasate. Significant spatial correlations were revealed between the DCE-US properties and tumour blood-oxygen saturation and haemoglobin, as estimated using OAI. It is speculated that DCE-US properties could be applied as surrogate biomarkers for hypoxia when planning clinical radiotherapy or chemotherapy. Elsevier 2017-08-30 /pmc/articles/PMC5596361/ /pubmed/28932684 http://dx.doi.org/10.1016/j.pacs.2017.08.001 Text en © 2017 Published by Elsevier GmbH. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Research Article
Shah, Anant
Bush, Nigel
Box, Gary
Eccles, Suzanne
Bamber, Jeffrey
Value of combining dynamic contrast enhanced ultrasound and optoacoustic tomography for hypoxia imaging
title Value of combining dynamic contrast enhanced ultrasound and optoacoustic tomography for hypoxia imaging
title_full Value of combining dynamic contrast enhanced ultrasound and optoacoustic tomography for hypoxia imaging
title_fullStr Value of combining dynamic contrast enhanced ultrasound and optoacoustic tomography for hypoxia imaging
title_full_unstemmed Value of combining dynamic contrast enhanced ultrasound and optoacoustic tomography for hypoxia imaging
title_short Value of combining dynamic contrast enhanced ultrasound and optoacoustic tomography for hypoxia imaging
title_sort value of combining dynamic contrast enhanced ultrasound and optoacoustic tomography for hypoxia imaging
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5596361/
https://www.ncbi.nlm.nih.gov/pubmed/28932684
http://dx.doi.org/10.1016/j.pacs.2017.08.001
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