Characterization of influenza A(H1N1)pdm09 viruses isolated from Nepalese and Indian outbreak patients in early 2015

We characterized influenza A(H1N1)pdm09 isolates from large‐scale outbreaks that occurred in Nepal and India in early 2015. Although no specific viral features, which may have caused the outbreaks, were identified, an S84N substitution in hemagglutinin was frequently observed. Chronological phylogen...

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Autores principales: Nakamura, Kazuya, Shirakura, Masayuki, Fujisaki, Seiichiro, Kishida, Noriko, Burke, David F., Smith, Derek J., Kuwahara, Tomoko, Takashita, Emi, Takayama, Ikuyo, Nakauchi, Mina, Chadha, Mandeep, Potdar, Varsha, Bhushan, Arvind, Upadhyay, Bishnu Prasad, Shakya, Geeta, Odagiri, Takato, Kageyama, Tsutomu, Watanabe, Shinji
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2017
Materias:
Short Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5596518/
https://www.ncbi.nlm.nih.gov/pubmed/28792671
http://dx.doi.org/10.1111/irv.12469
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author Nakamura, Kazuya
Shirakura, Masayuki
Fujisaki, Seiichiro
Kishida, Noriko
Burke, David F.
Smith, Derek J.
Kuwahara, Tomoko
Takashita, Emi
Takayama, Ikuyo
Nakauchi, Mina
Chadha, Mandeep
Potdar, Varsha
Bhushan, Arvind
Upadhyay, Bishnu Prasad
Shakya, Geeta
Odagiri, Takato
Kageyama, Tsutomu
Watanabe, Shinji
author_facet Nakamura, Kazuya
Shirakura, Masayuki
Fujisaki, Seiichiro
Kishida, Noriko
Burke, David F.
Smith, Derek J.
Kuwahara, Tomoko
Takashita, Emi
Takayama, Ikuyo
Nakauchi, Mina
Chadha, Mandeep
Potdar, Varsha
Bhushan, Arvind
Upadhyay, Bishnu Prasad
Shakya, Geeta
Odagiri, Takato
Kageyama, Tsutomu
Watanabe, Shinji
author_sort Nakamura, Kazuya
collection PubMed
description We characterized influenza A(H1N1)pdm09 isolates from large‐scale outbreaks that occurred in Nepal and India in early 2015. Although no specific viral features, which may have caused the outbreaks, were identified, an S84N substitution in hemagglutinin was frequently observed. Chronological phylogenetic analysis revealed that these Nepalese and Indian viruses possessing the S84N substitution constitute potential ancestors of the novel genetic subclade 6B.1 virus that spread globally in the following (2015/16) influenza season. Thus, active surveillance of circulating influenza viruses in the Southern Asia region, including Nepal and India, would be beneficial for detecting novel variant viruses prior to their worldwide spread.
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spelling pubmed-55965182017-09-15 Characterization of influenza A(H1N1)pdm09 viruses isolated from Nepalese and Indian outbreak patients in early 2015 Nakamura, Kazuya Shirakura, Masayuki Fujisaki, Seiichiro Kishida, Noriko Burke, David F. Smith, Derek J. Kuwahara, Tomoko Takashita, Emi Takayama, Ikuyo Nakauchi, Mina Chadha, Mandeep Potdar, Varsha Bhushan, Arvind Upadhyay, Bishnu Prasad Shakya, Geeta Odagiri, Takato Kageyama, Tsutomu Watanabe, Shinji Influenza Other Respir Viruses Short Article We characterized influenza A(H1N1)pdm09 isolates from large‐scale outbreaks that occurred in Nepal and India in early 2015. Although no specific viral features, which may have caused the outbreaks, were identified, an S84N substitution in hemagglutinin was frequently observed. Chronological phylogenetic analysis revealed that these Nepalese and Indian viruses possessing the S84N substitution constitute potential ancestors of the novel genetic subclade 6B.1 virus that spread globally in the following (2015/16) influenza season. Thus, active surveillance of circulating influenza viruses in the Southern Asia region, including Nepal and India, would be beneficial for detecting novel variant viruses prior to their worldwide spread. John Wiley and Sons Inc. 2017-08-09 2017-09 /pmc/articles/PMC5596518/ /pubmed/28792671 http://dx.doi.org/10.1111/irv.12469 Text en © 2017 The Authors. Influenza and Other Respiratory Viruses Published by John Wiley & Sons Ltd. This is an open access article under the terms of the Creative Commons Attribution (http://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Short Article
Nakamura, Kazuya
Shirakura, Masayuki
Fujisaki, Seiichiro
Kishida, Noriko
Burke, David F.
Smith, Derek J.
Kuwahara, Tomoko
Takashita, Emi
Takayama, Ikuyo
Nakauchi, Mina
Chadha, Mandeep
Potdar, Varsha
Bhushan, Arvind
Upadhyay, Bishnu Prasad
Shakya, Geeta
Odagiri, Takato
Kageyama, Tsutomu
Watanabe, Shinji
Characterization of influenza A(H1N1)pdm09 viruses isolated from Nepalese and Indian outbreak patients in early 2015
title Characterization of influenza A(H1N1)pdm09 viruses isolated from Nepalese and Indian outbreak patients in early 2015
title_full Characterization of influenza A(H1N1)pdm09 viruses isolated from Nepalese and Indian outbreak patients in early 2015
title_fullStr Characterization of influenza A(H1N1)pdm09 viruses isolated from Nepalese and Indian outbreak patients in early 2015
title_full_unstemmed Characterization of influenza A(H1N1)pdm09 viruses isolated from Nepalese and Indian outbreak patients in early 2015
title_short Characterization of influenza A(H1N1)pdm09 viruses isolated from Nepalese and Indian outbreak patients in early 2015
title_sort characterization of influenza a(h1n1)pdm09 viruses isolated from nepalese and indian outbreak patients in early 2015
topic Short Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5596518/
https://www.ncbi.nlm.nih.gov/pubmed/28792671
http://dx.doi.org/10.1111/irv.12469
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