Klotho enhances FoxO3-mediated manganese superoxide dismutase expression by negatively regulating PI3K/AKT pathway during tacrolimus-induced oxidative stress

Mammalian members of the forkhead box protein O (FoxO) class of transcription factors are implicated in the regulation of oxidative stress, and FoxO proteins are negatively regulated by the phosphatidylinositol 3-kinase (PI3K)–AKT signaling pathway. We examined the effect of Klotho on the PI3K/AKT p...

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Detalles Bibliográficos
Autores principales: Lim, Sun Woo, Jin, Long, Luo, Kang, Jin, Jian, Shin, Yoo Jin, Hong, Sung Yi, Yang, Chul Woo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5596554/
https://www.ncbi.nlm.nih.gov/pubmed/28771227
http://dx.doi.org/10.1038/cddis.2017.365

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