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Uev1A facilitates osteosarcoma differentiation by promoting Smurf1-mediated Smad1 ubiquitination and degradation

Malignant bone tumor osteosarcoma (OS) displays high metastasis incidence and poor prognosis. Its stem cell properties could serve to explain tumor recurrence and resistance to conventional treatments. In this study, we identified UEV1A as a novel suppressor of OS. Elevated UEV1A diminishes stem cel...

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Detalles Bibliográficos
Autores principales:	Zhang, Weiwei, Zhuang, Yuan, Zhang, Yiran, Yang, Xiaoran, Zhang, Hong, Wang, Guifen, Yin, Wanqi, Wang, Ruifeng, Zhang, Zhiling, Xiao, Wei
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2017
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5596555/ https://www.ncbi.nlm.nih.gov/pubmed/28771228 http://dx.doi.org/10.1038/cddis.2017.366

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