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PDI is an essential redox-sensitive activator of PERK during the unfolded protein response (UPR)

Endoplasmic reticulum (ER) stress leads to activation of the unfolded protein response (UPR) that results in transient suppression of protein translation to allow recovery but leads to cell death when stress cannot be resolved. Central to initiation of the UPR is the activation of the ER transmembra...

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Detalles Bibliográficos
Autores principales:	Kranz, Philip, Neumann, Fabian, Wolf, Alexandra, Classen, Fabian, Pompsch, Mosche, Ocklenburg, Tobias, Baumann, Jennifer, Janke, Kirsten, Baumann, Melanie, Goepelt, Kirsten, Riffkin, Helena, Metzen, Eric, Brockmeier, Ulf
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2017
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5596557/ https://www.ncbi.nlm.nih.gov/pubmed/28796255 http://dx.doi.org/10.1038/cddis.2017.369

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