Rho inhibition by lovastatin affects apoptosis and DSB repair of primary human lung cells in vitro and lung tissue in vivo following fractionated irradiation

Thoracic radiotherapy causes damage of normal lung tissue, which limits the cumulative radiation dose and, hence, confines the anticancer efficacy of radiotherapy and impacts the quality of life of tumor patients. Ras-homologous (Rho) small GTPases regulate multiple stress responses and cell death....

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Detalles Bibliográficos
Autores principales: Ziegler, Verena, Henninger, Christian, Simiantonakis, Ioannis, Buchholzer, Marcel, Ahmadian, Mohammad Reza, Budach, Wilfried, Fritz, Gerhard
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5596560/
https://www.ncbi.nlm.nih.gov/pubmed/28796249
http://dx.doi.org/10.1038/cddis.2017.372

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