Discovery of (4-bromophenyl)(3-hydroxy-4-methoxyphenyl)methanone through upregulating hTERT induces cell apoptosis and ERS

Dominant-negative mutants of telomerase hTERT were demonstrated to have selective effects in tumor cells. However, no any effective and highly selective hTERT inhibitor has been developed so far. We focused on developing new hTERT modulators and synthesized a small molecular compound, named (4-bromo...

Descripción completa

Detalles Bibliográficos
Autores principales: Cheng, Xiu, Shi, Jing Bo, Liu, Hao, Chen, Liu Zeng, Wang, Yang, Tang, Wen Jian, Liu, Xin Hua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5596570/
https://www.ncbi.nlm.nih.gov/pubmed/28837145
http://dx.doi.org/10.1038/cddis.2017.384

Ejemplares similares

Ejemplares similares