Sunitinib induces genomic instability of renal carcinoma cells through affecting the interaction of LC3-II and PARP-1

Deficiency of autophagy has been linked to increase in nuclear instability, but the role of autophagy in regulating the formation and elimination of micronuclei, a diagnostic marker for genomic instability, is limited in mammalian cells. Utilizing immunostaining and subcellular fractionation, we fou...

Descripción completa

Detalles Bibliográficos
Autores principales: Yan, Siyuan, Liu, Ling, Ren, Fengxia, Gao, Quan, Xu, Shanshan, Hou, Bolin, Wang, Yange, Jiang, Xuejun, Che, Yongsheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5596573/
https://www.ncbi.nlm.nih.gov/pubmed/28796254
http://dx.doi.org/10.1038/cddis.2017.387

Ejemplares similares

Ejemplares similares