IDH3 mediates apoptosis of alveolar epithelial cells type 2 due to mitochondrial Ca(2+) uptake during hypocapnia

In adult respiratory distress syndrome (ARDS) pulmonary perfusion failure increases physiologic dead-space (V(D)/V(T)) correlating with mortality. High V(D)/V(T) results in alveolar hypocapnia, which has been demonstrated to cause edema formation, atelectasis, and surfactant depletion, evoked, at le...

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Detalles Bibliográficos
Autores principales: Kiefmann, Martina, Tank, Sascha, Keller, Paula, Börnchen, Christian, Rinnenthal, Jan L, Tritt, Marc-Oliver, Schulte-Uentrop, Leonie, Olotu, Cynthia, Goetz, Alwin E, Kiefmann, Rainer
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5596584/
https://www.ncbi.nlm.nih.gov/pubmed/28837149
http://dx.doi.org/10.1038/cddis.2017.403

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