FGF1 protects neuroblastoma SH-SY5Y cells from p53-dependent apoptosis through an intracrine pathway regulated by FGF1 phosphorylation

Neuroblastoma, a sympathetic nervous system tumor, accounts for 15% of cancer deaths in children. In contrast to most human tumors, p53 is rarely mutated in human primary neuroblastoma, suggesting impaired p53 activation in neuroblastoma. Various studies have shown correlations between fgf1 expressi...

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Detalles Bibliográficos
Autores principales: Pirou, Caroline, Montazer-Torbati, Fatemeh, Jah, Nadège, Delmas, Elisabeth, Lasbleiz, Christelle, Mignotte, Bernard, Renaud, Flore
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5596585/
https://www.ncbi.nlm.nih.gov/pubmed/29048426
http://dx.doi.org/10.1038/cddis.2017.404

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