Cardioprotective effects of fibroblast growth factor 21 against doxorubicin-induced toxicity via the SIRT1/LKB1/AMPK pathway

Doxorubicin (DOX) is a highly effective antineoplastic anthracycline drug; however, the adverse effect of the cardiotoxicity has limited its widespread application. Fibroblast growth factor 21 (FGF21), as a well-known regulator of glucose and lipid metabolism, was recently shown to exert cardioprote...

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Detalles Bibliográficos
Autores principales: Wang, Shudong, Wang, Yonggang, Zhang, Zhiguo, Liu, Quan, Gu, Junlian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5596591/
https://www.ncbi.nlm.nih.gov/pubmed/28837153
http://dx.doi.org/10.1038/cddis.2017.410

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