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AKT2 suppresses pro-survival autophagy triggered by DNA double-strand breaks in colorectal cancer cells

DNA double-strand breaks (DSBs) are critical DNA lesions, which threaten genome stability and cell survival. DSBs are directly induced by ionizing radiation (IR) and radiomimetic agents, including the cytolethal distending toxin (CDT). This bacterial genotoxin harbors a unique DNase-I-like endonucle...

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Detalles Bibliográficos
Autores principales:	Seiwert, Nina, Neitzel, Carina, Stroh, Svenja, Frisan, Teresa, Audebert, Marc, Toulany, Mahmoud, Kaina, Bernd, Fahrer, Jörg
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2017
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5596597/ https://www.ncbi.nlm.nih.gov/pubmed/28837154 http://dx.doi.org/10.1038/cddis.2017.418

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