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Clinicopathological Characteristics of Papillary Thyroid Cancer in Children with Emphasis on Pubertal Status and Association with BRAFV600E Mutation
OBJECTIVE: Papillary thyroid cancer (PTC) may behave differently in prepubertal children as compared to pubertal children and adults. BRAF gene activating mutations may associate with PTC by creating aberrant activation. We aimed to evaluate the clinicopathological characteristics of PTC patients wi...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Galenos Publishing
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5596798/ https://www.ncbi.nlm.nih.gov/pubmed/28077340 http://dx.doi.org/10.4274/jcrpe.3873 |
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author | Poyrazoğlu, Şükran Bundak, Rüveyde Baş, Firdevs Yeğen, Gülçin Şanlı, Yasemin Darendeliler, Feyza |
author_facet | Poyrazoğlu, Şükran Bundak, Rüveyde Baş, Firdevs Yeğen, Gülçin Şanlı, Yasemin Darendeliler, Feyza |
author_sort | Poyrazoğlu, Şükran |
collection | PubMed |
description | OBJECTIVE: Papillary thyroid cancer (PTC) may behave differently in prepubertal children as compared to pubertal children and adults. BRAF gene activating mutations may associate with PTC by creating aberrant activation. We aimed to evaluate the clinicopathological characteristics of PTC patients with emphasis on the pubertal status and also to investigate the association of BRAF(V600E) mutation with disease characteristics. METHODS: The medical records of 75 patients with PTC were reviewed retrospectively. BRAF(V600E) mutation status was available only in the medical records of 56 patients. RESULTS: Mean age at diagnosis was 12.4±3.8 years. There was no difference in sex, initial signs, tumor histopathology, and pathological evidence of tumor aggressiveness between prepubertal and pubertal children. Although not statistically significant, lateral neck nodal metastasis and lung metastasis at diagnosis were more prevalent in prepubertal children. After excluding patients with microcarcinoma, prepubertal children were found to require lateral neck dissection and further doses of radioactive iodine more frequently than pubertal patients. Recurrence was also more frequent in prepubertal children (p=0.016). Frequency of BRAF(V600E) mutation was similar in prepubertal and pubertal patients. BRAF(V600E) mutation was found in 14/56 (25%) patients and was high in the classic variant PTC (p=0.004). Multicentricity was high in BRAF(V600E) mutation (p=0.01). There was no relation between BRAF(V600E) mutation and lymph node and pulmonary metastasis at diagnosis, or between BRAF(V600E) mutation and pathological evidence of tumor aggressiveness. CONCLUSION: PTC is more disseminated in prepubertal children. BRAF(V600E) mutation does not correlate with a more extensive or aggressive disease. BRAF(V600E) mutation is not the cause of the differences in the biological behavior of PTC in prepubertal and pubertal children. |
format | Online Article Text |
id | pubmed-5596798 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Galenos Publishing |
record_format | MEDLINE/PubMed |
spelling | pubmed-55967982017-09-18 Clinicopathological Characteristics of Papillary Thyroid Cancer in Children with Emphasis on Pubertal Status and Association with BRAFV600E Mutation Poyrazoğlu, Şükran Bundak, Rüveyde Baş, Firdevs Yeğen, Gülçin Şanlı, Yasemin Darendeliler, Feyza J Clin Res Pediatr Endocrinol Original Article OBJECTIVE: Papillary thyroid cancer (PTC) may behave differently in prepubertal children as compared to pubertal children and adults. BRAF gene activating mutations may associate with PTC by creating aberrant activation. We aimed to evaluate the clinicopathological characteristics of PTC patients with emphasis on the pubertal status and also to investigate the association of BRAF(V600E) mutation with disease characteristics. METHODS: The medical records of 75 patients with PTC were reviewed retrospectively. BRAF(V600E) mutation status was available only in the medical records of 56 patients. RESULTS: Mean age at diagnosis was 12.4±3.8 years. There was no difference in sex, initial signs, tumor histopathology, and pathological evidence of tumor aggressiveness between prepubertal and pubertal children. Although not statistically significant, lateral neck nodal metastasis and lung metastasis at diagnosis were more prevalent in prepubertal children. After excluding patients with microcarcinoma, prepubertal children were found to require lateral neck dissection and further doses of radioactive iodine more frequently than pubertal patients. Recurrence was also more frequent in prepubertal children (p=0.016). Frequency of BRAF(V600E) mutation was similar in prepubertal and pubertal patients. BRAF(V600E) mutation was found in 14/56 (25%) patients and was high in the classic variant PTC (p=0.004). Multicentricity was high in BRAF(V600E) mutation (p=0.01). There was no relation between BRAF(V600E) mutation and lymph node and pulmonary metastasis at diagnosis, or between BRAF(V600E) mutation and pathological evidence of tumor aggressiveness. CONCLUSION: PTC is more disseminated in prepubertal children. BRAF(V600E) mutation does not correlate with a more extensive or aggressive disease. BRAF(V600E) mutation is not the cause of the differences in the biological behavior of PTC in prepubertal and pubertal children. Galenos Publishing 2017-09 2017-09-01 /pmc/articles/PMC5596798/ /pubmed/28077340 http://dx.doi.org/10.4274/jcrpe.3873 Text en ©Copyright 2017 by Turkish Pediatric Endocrinology and Diabetes Society The Journal of Clinical Research in Pediatric Endocrinology published by Galenos Publishing House. http://creativecommons.org/licenses/by/2.5/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Poyrazoğlu, Şükran Bundak, Rüveyde Baş, Firdevs Yeğen, Gülçin Şanlı, Yasemin Darendeliler, Feyza Clinicopathological Characteristics of Papillary Thyroid Cancer in Children with Emphasis on Pubertal Status and Association with BRAFV600E Mutation |
title | Clinicopathological Characteristics of Papillary Thyroid Cancer in Children with Emphasis on Pubertal Status and Association with BRAFV600E Mutation |
title_full | Clinicopathological Characteristics of Papillary Thyroid Cancer in Children with Emphasis on Pubertal Status and Association with BRAFV600E Mutation |
title_fullStr | Clinicopathological Characteristics of Papillary Thyroid Cancer in Children with Emphasis on Pubertal Status and Association with BRAFV600E Mutation |
title_full_unstemmed | Clinicopathological Characteristics of Papillary Thyroid Cancer in Children with Emphasis on Pubertal Status and Association with BRAFV600E Mutation |
title_short | Clinicopathological Characteristics of Papillary Thyroid Cancer in Children with Emphasis on Pubertal Status and Association with BRAFV600E Mutation |
title_sort | clinicopathological characteristics of papillary thyroid cancer in children with emphasis on pubertal status and association with brafv600e mutation |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5596798/ https://www.ncbi.nlm.nih.gov/pubmed/28077340 http://dx.doi.org/10.4274/jcrpe.3873 |
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