Crx-L253X Mutation Produces Dominant Photoreceptor Defects in TVRM65 Mice

PURPOSE: The cone-rod homeobox (CRX) transcription factor is essential for photoreceptor gene expression, differentiation, and survival. Human CRX mutations can cause dominant retinopathies of varying onset and phenotype severity. In animal models, dominant frameshift Crx mutations introduce a prema...

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Detalles Bibliográficos
Autores principales: Ruzycki, Philip A., Linne, Courtney D., Hennig, Anne K., Chen, Shiming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Association for Research in Vision and Ophthalmology 2017
Materias:
Biochemistry and Molecular Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5597032/
https://www.ncbi.nlm.nih.gov/pubmed/28903150
http://dx.doi.org/10.1167/iovs.17-22075

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5597032/
https://www.ncbi.nlm.nih.gov/pubmed/28903150
http://dx.doi.org/10.1167/iovs.17-22075

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