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The Irisin Hormone Profile and Expression in Human Bone Tissue in the Bone Healing Process in Patients

BACKGROUND: Whether or not there is a relationship between the newly-discovered irisin hormone and bone healing is not yet known. The aim of this study was to investigate what effect irisin hormone has on the bone healing process. MATERIAL/METHODS: The study included 21 adult patients with a diagnos...

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Autores principales: Serbest, Sancar, Tiftikçi, Uğur, Tosun, Hacı Bayram, Kısa, Üçler
Formato: Online Artículo Texto
Lenguaje:English
Publicado: International Scientific Literature, Inc. 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5597035/
https://www.ncbi.nlm.nih.gov/pubmed/28869754
http://dx.doi.org/10.12659/MSM.906293
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author Serbest, Sancar
Tiftikçi, Uğur
Tosun, Hacı Bayram
Kısa, Üçler
author_facet Serbest, Sancar
Tiftikçi, Uğur
Tosun, Hacı Bayram
Kısa, Üçler
author_sort Serbest, Sancar
collection PubMed
description BACKGROUND: Whether or not there is a relationship between the newly-discovered irisin hormone and bone healing is not yet known. The aim of this study was to investigate what effect irisin hormone has on the bone healing process. MATERIAL/METHODS: The study included 21 adult patients with a diagnosed fracture of the lower extremity (femur or tibia). Informed consent was obtained from all the patients. A total of four venous blood samples were taken from the patients: before fracture stabilization, then postoperatively on days 1, 10, and 60. In patients with femoral neck fracture who had hip prosthesis applied, bone tissue samples were taken from the removed femur head and irisin was determined immunohistochemically in muscle biopsies taken from the same patients. RESULTS: In analysis, it was revealed that the mean value of irisin 60 days after operation is significantly higher than the values of irisin before operation, 1 day after operation, and 15 day after operation (p<0.001, p<0.001, p<0.001, respectively). Intense staining was observed in compact bone tissue, muscle tissue, and in hypertrophic vascular endothelium within the Havers canal. CONCLUSIONS: The level of irisin hormone increased in the bone union process and affects fracture healing due to irisin receptors in human bone tissue.
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spelling pubmed-55970352017-09-20 The Irisin Hormone Profile and Expression in Human Bone Tissue in the Bone Healing Process in Patients Serbest, Sancar Tiftikçi, Uğur Tosun, Hacı Bayram Kısa, Üçler Med Sci Monit Clinical Research BACKGROUND: Whether or not there is a relationship between the newly-discovered irisin hormone and bone healing is not yet known. The aim of this study was to investigate what effect irisin hormone has on the bone healing process. MATERIAL/METHODS: The study included 21 adult patients with a diagnosed fracture of the lower extremity (femur or tibia). Informed consent was obtained from all the patients. A total of four venous blood samples were taken from the patients: before fracture stabilization, then postoperatively on days 1, 10, and 60. In patients with femoral neck fracture who had hip prosthesis applied, bone tissue samples were taken from the removed femur head and irisin was determined immunohistochemically in muscle biopsies taken from the same patients. RESULTS: In analysis, it was revealed that the mean value of irisin 60 days after operation is significantly higher than the values of irisin before operation, 1 day after operation, and 15 day after operation (p<0.001, p<0.001, p<0.001, respectively). Intense staining was observed in compact bone tissue, muscle tissue, and in hypertrophic vascular endothelium within the Havers canal. CONCLUSIONS: The level of irisin hormone increased in the bone union process and affects fracture healing due to irisin receptors in human bone tissue. International Scientific Literature, Inc. 2017-09-04 /pmc/articles/PMC5597035/ /pubmed/28869754 http://dx.doi.org/10.12659/MSM.906293 Text en © Med Sci Monit, 2017 This work is licensed under Creative Common Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0 (https://creativecommons.org/licenses/by-nc-nd/4.0/) )
spellingShingle Clinical Research
Serbest, Sancar
Tiftikçi, Uğur
Tosun, Hacı Bayram
Kısa, Üçler
The Irisin Hormone Profile and Expression in Human Bone Tissue in the Bone Healing Process in Patients
title The Irisin Hormone Profile and Expression in Human Bone Tissue in the Bone Healing Process in Patients
title_full The Irisin Hormone Profile and Expression in Human Bone Tissue in the Bone Healing Process in Patients
title_fullStr The Irisin Hormone Profile and Expression in Human Bone Tissue in the Bone Healing Process in Patients
title_full_unstemmed The Irisin Hormone Profile and Expression in Human Bone Tissue in the Bone Healing Process in Patients
title_short The Irisin Hormone Profile and Expression in Human Bone Tissue in the Bone Healing Process in Patients
title_sort irisin hormone profile and expression in human bone tissue in the bone healing process in patients
topic Clinical Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5597035/
https://www.ncbi.nlm.nih.gov/pubmed/28869754
http://dx.doi.org/10.12659/MSM.906293
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