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The rat retrosplenial cortex as a link for frontal functions: A lesion analysis

Cohorts of rats with excitotoxic retrosplenial cortex lesions were tested on four behavioural tasks sensitive to dysfunctions in prelimbic cortex, anterior cingulate cortex, or both. In this way the study tested whether retrosplenial cortex has nonspatial functions that reflect its anatomical intera...

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Autores principales: Powell, Anna L., Nelson, Andrew J.D., Hindley, Emma, Davies, Moira, Aggleton, John P., Vann, Seralynne D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier/North-Holland Biomedical Press 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5597037/
https://www.ncbi.nlm.nih.gov/pubmed/28797600
http://dx.doi.org/10.1016/j.bbr.2017.08.010
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author Powell, Anna L.
Nelson, Andrew J.D.
Hindley, Emma
Davies, Moira
Aggleton, John P.
Vann, Seralynne D.
author_facet Powell, Anna L.
Nelson, Andrew J.D.
Hindley, Emma
Davies, Moira
Aggleton, John P.
Vann, Seralynne D.
author_sort Powell, Anna L.
collection PubMed
description Cohorts of rats with excitotoxic retrosplenial cortex lesions were tested on four behavioural tasks sensitive to dysfunctions in prelimbic cortex, anterior cingulate cortex, or both. In this way the study tested whether retrosplenial cortex has nonspatial functions that reflect its anatomical interactions with these frontal cortical areas. In Experiment 1, retrosplenial cortex lesions had no apparent effect on a set-shifting digging task that taxed intradimensional and extradimensional attention, as well as reversal learning. Likewise, retrosplenial cortex lesions did not impair a strategy shift task in an automated chamber, which involved switching from visual-based to response-based discriminations and, again, included a reversal (Experiment 2). Indeed, there was evidence that the retrosplenial lesions aided the initial switch to response-based selection. No lesion deficit was found on an automated cost-benefit task that pitted size of reward against effort to achieve that reward (Experiment 3). Finally, while retrosplenial cortex lesions affected matching-to-place task in a T-maze, the profile of deficits differed from that associated with prelimbic cortex damage (Experiment 4). When the task was switched to a nonmatching design, retrosplenial cortex lesions had no apparent effect on performance. The results from the four experiments show that many frontal tasks do not require the retrosplenial cortex, highlighting the specificity of their functional interactions. The results show how retrosplenial cortex lesions spare those learning tasks in which there is no mismatch between the internal and external representations used to guide behavioural choice. In addition, these experiments further highlight the importance of the retrosplenial cortex in solving tasks with a spatial component.
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spelling pubmed-55970372017-09-29 The rat retrosplenial cortex as a link for frontal functions: A lesion analysis Powell, Anna L. Nelson, Andrew J.D. Hindley, Emma Davies, Moira Aggleton, John P. Vann, Seralynne D. Behav Brain Res Research Report Cohorts of rats with excitotoxic retrosplenial cortex lesions were tested on four behavioural tasks sensitive to dysfunctions in prelimbic cortex, anterior cingulate cortex, or both. In this way the study tested whether retrosplenial cortex has nonspatial functions that reflect its anatomical interactions with these frontal cortical areas. In Experiment 1, retrosplenial cortex lesions had no apparent effect on a set-shifting digging task that taxed intradimensional and extradimensional attention, as well as reversal learning. Likewise, retrosplenial cortex lesions did not impair a strategy shift task in an automated chamber, which involved switching from visual-based to response-based discriminations and, again, included a reversal (Experiment 2). Indeed, there was evidence that the retrosplenial lesions aided the initial switch to response-based selection. No lesion deficit was found on an automated cost-benefit task that pitted size of reward against effort to achieve that reward (Experiment 3). Finally, while retrosplenial cortex lesions affected matching-to-place task in a T-maze, the profile of deficits differed from that associated with prelimbic cortex damage (Experiment 4). When the task was switched to a nonmatching design, retrosplenial cortex lesions had no apparent effect on performance. The results from the four experiments show that many frontal tasks do not require the retrosplenial cortex, highlighting the specificity of their functional interactions. The results show how retrosplenial cortex lesions spare those learning tasks in which there is no mismatch between the internal and external representations used to guide behavioural choice. In addition, these experiments further highlight the importance of the retrosplenial cortex in solving tasks with a spatial component. Elsevier/North-Holland Biomedical Press 2017-09-29 /pmc/articles/PMC5597037/ /pubmed/28797600 http://dx.doi.org/10.1016/j.bbr.2017.08.010 Text en © 2017 The Authors http://creativecommons.org/licenses/by/4.0/ This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Research Report
Powell, Anna L.
Nelson, Andrew J.D.
Hindley, Emma
Davies, Moira
Aggleton, John P.
Vann, Seralynne D.
The rat retrosplenial cortex as a link for frontal functions: A lesion analysis
title The rat retrosplenial cortex as a link for frontal functions: A lesion analysis
title_full The rat retrosplenial cortex as a link for frontal functions: A lesion analysis
title_fullStr The rat retrosplenial cortex as a link for frontal functions: A lesion analysis
title_full_unstemmed The rat retrosplenial cortex as a link for frontal functions: A lesion analysis
title_short The rat retrosplenial cortex as a link for frontal functions: A lesion analysis
title_sort rat retrosplenial cortex as a link for frontal functions: a lesion analysis
topic Research Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5597037/
https://www.ncbi.nlm.nih.gov/pubmed/28797600
http://dx.doi.org/10.1016/j.bbr.2017.08.010
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