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Transient Mechanical Response of Lung Airway Tissue during Mechanical Ventilation

Patients with acute lung injury, airway and other pulmonary diseases often require Mechanical Ventilation (MV). Knowledge of the stress/strain environment in lung airway tissues is very important in order to avoid lung injuries for patients undergoing MV. Airway tissue strains responsible for stress...

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Detalles Bibliográficos
Autores principales: Ibrahim, Israr Bin Muhammad, Aghasafari, Parya, Pidaparti, Ramana M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5597162/
https://www.ncbi.nlm.nih.gov/pubmed/28952566
http://dx.doi.org/10.3390/bioengineering3010004
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author Ibrahim, Israr Bin Muhammad
Aghasafari, Parya
Pidaparti, Ramana M.
author_facet Ibrahim, Israr Bin Muhammad
Aghasafari, Parya
Pidaparti, Ramana M.
author_sort Ibrahim, Israr Bin Muhammad
collection PubMed
description Patients with acute lung injury, airway and other pulmonary diseases often require Mechanical Ventilation (MV). Knowledge of the stress/strain environment in lung airway tissues is very important in order to avoid lung injuries for patients undergoing MV. Airway tissue strains responsible for stressing the lung’s fiber network and rupturing the lung due to compliant airways are very difficult to measure experimentally. Multi-level modeling is adopted to investigate the transient mechanical response of the tissue under MV. First, airflow through a lung airway bifurcation (Generation 4–6) is modeled using Computational Fluid Dynamics (CFD) to obtain air pressure during 2 seconds of MV breathing. Next, the transient air pressure was used in structural analysis to obtain mechanical strain experienced by the airway tissue wall. Structural analysis showed that airway tissue from Generation 5 in one bifurcation can stretch eight times that of airway tissue of the same generation number but with different bifurcation. The results suggest sensitivity of load to geometrical features. Furthermore, the results of strain levels obtained from the tissue analysis are very important because these strains at the cellular-level can create inflammatory responses, thus damaging the airway tissues.
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spelling pubmed-55971622017-09-21 Transient Mechanical Response of Lung Airway Tissue during Mechanical Ventilation Ibrahim, Israr Bin Muhammad Aghasafari, Parya Pidaparti, Ramana M. Bioengineering (Basel) Article Patients with acute lung injury, airway and other pulmonary diseases often require Mechanical Ventilation (MV). Knowledge of the stress/strain environment in lung airway tissues is very important in order to avoid lung injuries for patients undergoing MV. Airway tissue strains responsible for stressing the lung’s fiber network and rupturing the lung due to compliant airways are very difficult to measure experimentally. Multi-level modeling is adopted to investigate the transient mechanical response of the tissue under MV. First, airflow through a lung airway bifurcation (Generation 4–6) is modeled using Computational Fluid Dynamics (CFD) to obtain air pressure during 2 seconds of MV breathing. Next, the transient air pressure was used in structural analysis to obtain mechanical strain experienced by the airway tissue wall. Structural analysis showed that airway tissue from Generation 5 in one bifurcation can stretch eight times that of airway tissue of the same generation number but with different bifurcation. The results suggest sensitivity of load to geometrical features. Furthermore, the results of strain levels obtained from the tissue analysis are very important because these strains at the cellular-level can create inflammatory responses, thus damaging the airway tissues. MDPI 2016-01-05 /pmc/articles/PMC5597162/ /pubmed/28952566 http://dx.doi.org/10.3390/bioengineering3010004 Text en © 2016 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons by Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Ibrahim, Israr Bin Muhammad
Aghasafari, Parya
Pidaparti, Ramana M.
Transient Mechanical Response of Lung Airway Tissue during Mechanical Ventilation
title Transient Mechanical Response of Lung Airway Tissue during Mechanical Ventilation
title_full Transient Mechanical Response of Lung Airway Tissue during Mechanical Ventilation
title_fullStr Transient Mechanical Response of Lung Airway Tissue during Mechanical Ventilation
title_full_unstemmed Transient Mechanical Response of Lung Airway Tissue during Mechanical Ventilation
title_short Transient Mechanical Response of Lung Airway Tissue during Mechanical Ventilation
title_sort transient mechanical response of lung airway tissue during mechanical ventilation
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5597162/
https://www.ncbi.nlm.nih.gov/pubmed/28952566
http://dx.doi.org/10.3390/bioengineering3010004
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