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Metabolic Control in Mammalian Fed-Batch Cell Cultures for Reduced Lactic Acid Accumulation and Improved Process Robustness

Biomass and cell-specific metabolic rates usually change dynamically over time, making the “feed according to need” strategy difficult to realize in a commercial fed-batch process. We here demonstrate a novel feeding strategy which is designed to hold a particular metabolic state in a fed-batch proc...

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Detalles Bibliográficos
Autores principales:	Konakovsky, Viktor, Clemens, Christoph, Müller, Markus Michael, Bechmann, Jan, Berger, Martina, Schlatter, Stefan, Herwig, Christoph
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2016
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5597163/ https://www.ncbi.nlm.nih.gov/pubmed/28952567 http://dx.doi.org/10.3390/bioengineering3010005

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