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PreImplantation Factor in endometriosis: A potential role in inducing immune privilege for ectopic endometrium
Endometriosis is a chronic inflammatory condition characterised by the growth of endometrial epithelial and stromal cells outside the uterine cavity. In addition to Sampson’s theory of retrograde menstruation, endometriosis pathogenesis is facilitated by a privileged inflammatory microenvironment, w...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5597204/ https://www.ncbi.nlm.nih.gov/pubmed/28902871 http://dx.doi.org/10.1371/journal.pone.0184399 |
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author | Sbracia, Marco McKinnon, Brett Scarpellini, Fabio Marconi, Daniela Rossi, Gabriele Simmilion, Cedric Mueller, Michael D. Barnea, Eytan R. Mueller, Martin |
author_facet | Sbracia, Marco McKinnon, Brett Scarpellini, Fabio Marconi, Daniela Rossi, Gabriele Simmilion, Cedric Mueller, Michael D. Barnea, Eytan R. Mueller, Martin |
author_sort | Sbracia, Marco |
collection | PubMed |
description | Endometriosis is a chronic inflammatory condition characterised by the growth of endometrial epithelial and stromal cells outside the uterine cavity. In addition to Sampson’s theory of retrograde menstruation, endometriosis pathogenesis is facilitated by a privileged inflammatory microenvironment, with T regulatory FoxP3(+) expressing T cells (Tregs) being a significant factor. PreImplantation Factor (PIF) is a peptide essential for pregnancy recognition and development. An immune modulatory function of the synthetic PIF analog (sPIF) has been successfully confirmed in multiple animal models. We report that PIF is expressed in the epithelial ectopic cells in close proximity to FoxP3(+) stromal cells. We provide evidence that PIF interacts with FoxP3(+) cells and modulates cell viability, dependent on cell source and presence of inflammatory mediators. Our finding represent a novel PIF-based mechanism in endometriosis that has potential for novel therapeutics. |
format | Online Article Text |
id | pubmed-5597204 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-55972042017-09-15 PreImplantation Factor in endometriosis: A potential role in inducing immune privilege for ectopic endometrium Sbracia, Marco McKinnon, Brett Scarpellini, Fabio Marconi, Daniela Rossi, Gabriele Simmilion, Cedric Mueller, Michael D. Barnea, Eytan R. Mueller, Martin PLoS One Research Article Endometriosis is a chronic inflammatory condition characterised by the growth of endometrial epithelial and stromal cells outside the uterine cavity. In addition to Sampson’s theory of retrograde menstruation, endometriosis pathogenesis is facilitated by a privileged inflammatory microenvironment, with T regulatory FoxP3(+) expressing T cells (Tregs) being a significant factor. PreImplantation Factor (PIF) is a peptide essential for pregnancy recognition and development. An immune modulatory function of the synthetic PIF analog (sPIF) has been successfully confirmed in multiple animal models. We report that PIF is expressed in the epithelial ectopic cells in close proximity to FoxP3(+) stromal cells. We provide evidence that PIF interacts with FoxP3(+) cells and modulates cell viability, dependent on cell source and presence of inflammatory mediators. Our finding represent a novel PIF-based mechanism in endometriosis that has potential for novel therapeutics. Public Library of Science 2017-09-13 /pmc/articles/PMC5597204/ /pubmed/28902871 http://dx.doi.org/10.1371/journal.pone.0184399 Text en © 2017 Sbracia et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Article Sbracia, Marco McKinnon, Brett Scarpellini, Fabio Marconi, Daniela Rossi, Gabriele Simmilion, Cedric Mueller, Michael D. Barnea, Eytan R. Mueller, Martin PreImplantation Factor in endometriosis: A potential role in inducing immune privilege for ectopic endometrium |
title | PreImplantation Factor in endometriosis: A potential role in inducing immune privilege for ectopic endometrium |
title_full | PreImplantation Factor in endometriosis: A potential role in inducing immune privilege for ectopic endometrium |
title_fullStr | PreImplantation Factor in endometriosis: A potential role in inducing immune privilege for ectopic endometrium |
title_full_unstemmed | PreImplantation Factor in endometriosis: A potential role in inducing immune privilege for ectopic endometrium |
title_short | PreImplantation Factor in endometriosis: A potential role in inducing immune privilege for ectopic endometrium |
title_sort | preimplantation factor in endometriosis: a potential role in inducing immune privilege for ectopic endometrium |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5597204/ https://www.ncbi.nlm.nih.gov/pubmed/28902871 http://dx.doi.org/10.1371/journal.pone.0184399 |
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