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PreImplantation Factor in endometriosis: A potential role in inducing immune privilege for ectopic endometrium

Endometriosis is a chronic inflammatory condition characterised by the growth of endometrial epithelial and stromal cells outside the uterine cavity. In addition to Sampson’s theory of retrograde menstruation, endometriosis pathogenesis is facilitated by a privileged inflammatory microenvironment, w...

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Autores principales: Sbracia, Marco, McKinnon, Brett, Scarpellini, Fabio, Marconi, Daniela, Rossi, Gabriele, Simmilion, Cedric, Mueller, Michael D., Barnea, Eytan R., Mueller, Martin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5597204/
https://www.ncbi.nlm.nih.gov/pubmed/28902871
http://dx.doi.org/10.1371/journal.pone.0184399
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author Sbracia, Marco
McKinnon, Brett
Scarpellini, Fabio
Marconi, Daniela
Rossi, Gabriele
Simmilion, Cedric
Mueller, Michael D.
Barnea, Eytan R.
Mueller, Martin
author_facet Sbracia, Marco
McKinnon, Brett
Scarpellini, Fabio
Marconi, Daniela
Rossi, Gabriele
Simmilion, Cedric
Mueller, Michael D.
Barnea, Eytan R.
Mueller, Martin
author_sort Sbracia, Marco
collection PubMed
description Endometriosis is a chronic inflammatory condition characterised by the growth of endometrial epithelial and stromal cells outside the uterine cavity. In addition to Sampson’s theory of retrograde menstruation, endometriosis pathogenesis is facilitated by a privileged inflammatory microenvironment, with T regulatory FoxP3(+) expressing T cells (Tregs) being a significant factor. PreImplantation Factor (PIF) is a peptide essential for pregnancy recognition and development. An immune modulatory function of the synthetic PIF analog (sPIF) has been successfully confirmed in multiple animal models. We report that PIF is expressed in the epithelial ectopic cells in close proximity to FoxP3(+) stromal cells. We provide evidence that PIF interacts with FoxP3(+) cells and modulates cell viability, dependent on cell source and presence of inflammatory mediators. Our finding represent a novel PIF-based mechanism in endometriosis that has potential for novel therapeutics.
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spelling pubmed-55972042017-09-15 PreImplantation Factor in endometriosis: A potential role in inducing immune privilege for ectopic endometrium Sbracia, Marco McKinnon, Brett Scarpellini, Fabio Marconi, Daniela Rossi, Gabriele Simmilion, Cedric Mueller, Michael D. Barnea, Eytan R. Mueller, Martin PLoS One Research Article Endometriosis is a chronic inflammatory condition characterised by the growth of endometrial epithelial and stromal cells outside the uterine cavity. In addition to Sampson’s theory of retrograde menstruation, endometriosis pathogenesis is facilitated by a privileged inflammatory microenvironment, with T regulatory FoxP3(+) expressing T cells (Tregs) being a significant factor. PreImplantation Factor (PIF) is a peptide essential for pregnancy recognition and development. An immune modulatory function of the synthetic PIF analog (sPIF) has been successfully confirmed in multiple animal models. We report that PIF is expressed in the epithelial ectopic cells in close proximity to FoxP3(+) stromal cells. We provide evidence that PIF interacts with FoxP3(+) cells and modulates cell viability, dependent on cell source and presence of inflammatory mediators. Our finding represent a novel PIF-based mechanism in endometriosis that has potential for novel therapeutics. Public Library of Science 2017-09-13 /pmc/articles/PMC5597204/ /pubmed/28902871 http://dx.doi.org/10.1371/journal.pone.0184399 Text en © 2017 Sbracia et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Sbracia, Marco
McKinnon, Brett
Scarpellini, Fabio
Marconi, Daniela
Rossi, Gabriele
Simmilion, Cedric
Mueller, Michael D.
Barnea, Eytan R.
Mueller, Martin
PreImplantation Factor in endometriosis: A potential role in inducing immune privilege for ectopic endometrium
title PreImplantation Factor in endometriosis: A potential role in inducing immune privilege for ectopic endometrium
title_full PreImplantation Factor in endometriosis: A potential role in inducing immune privilege for ectopic endometrium
title_fullStr PreImplantation Factor in endometriosis: A potential role in inducing immune privilege for ectopic endometrium
title_full_unstemmed PreImplantation Factor in endometriosis: A potential role in inducing immune privilege for ectopic endometrium
title_short PreImplantation Factor in endometriosis: A potential role in inducing immune privilege for ectopic endometrium
title_sort preimplantation factor in endometriosis: a potential role in inducing immune privilege for ectopic endometrium
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5597204/
https://www.ncbi.nlm.nih.gov/pubmed/28902871
http://dx.doi.org/10.1371/journal.pone.0184399
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