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Bridging the dynamics and organization of chromatin domains by mathematical modeling
The genome is 3-dimensionally organized in the cell, and the mammalian genome DNA is partitioned into submegabase-sized chromatin domains. Genome functions are regulated within and across the domains according to their organization, whereas the chromatin itself is highly dynamic. However, the detail...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Taylor & Francis
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5597300/ https://www.ncbi.nlm.nih.gov/pubmed/28406741 http://dx.doi.org/10.1080/19491034.2017.1313937 |
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author | Shinkai, Soya Nozaki, Tadasu Maeshima, Kazuhiro Togashi, Yuichi |
author_facet | Shinkai, Soya Nozaki, Tadasu Maeshima, Kazuhiro Togashi, Yuichi |
author_sort | Shinkai, Soya |
collection | PubMed |
description | The genome is 3-dimensionally organized in the cell, and the mammalian genome DNA is partitioned into submegabase-sized chromatin domains. Genome functions are regulated within and across the domains according to their organization, whereas the chromatin itself is highly dynamic. However, the details of such dynamic organization of chromatin domains in living cells remain unclear. To unify chromatin dynamics and organization, we recently demonstrated that structural information of chromatin domains in living human cells can be extracted from analyses of the subdiffusive nucleosome movement using mathematical modeling. Our mathematical analysis suggested that as the chromatin domain becomes smaller and more compact, nucleosome movement becomes increasingly restricted. Here, we show the implication of these results for bridging the gap between chromatin dynamics and organization, and provide physical insight into chromatin domains as efficient units to conduct genome functions in the thermal noisy environment of the cell. |
format | Online Article Text |
id | pubmed-5597300 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Taylor & Francis |
record_format | MEDLINE/PubMed |
spelling | pubmed-55973002017-09-18 Bridging the dynamics and organization of chromatin domains by mathematical modeling Shinkai, Soya Nozaki, Tadasu Maeshima, Kazuhiro Togashi, Yuichi Nucleus Extra View The genome is 3-dimensionally organized in the cell, and the mammalian genome DNA is partitioned into submegabase-sized chromatin domains. Genome functions are regulated within and across the domains according to their organization, whereas the chromatin itself is highly dynamic. However, the details of such dynamic organization of chromatin domains in living cells remain unclear. To unify chromatin dynamics and organization, we recently demonstrated that structural information of chromatin domains in living human cells can be extracted from analyses of the subdiffusive nucleosome movement using mathematical modeling. Our mathematical analysis suggested that as the chromatin domain becomes smaller and more compact, nucleosome movement becomes increasingly restricted. Here, we show the implication of these results for bridging the gap between chromatin dynamics and organization, and provide physical insight into chromatin domains as efficient units to conduct genome functions in the thermal noisy environment of the cell. Taylor & Francis 2017-04-13 /pmc/articles/PMC5597300/ /pubmed/28406741 http://dx.doi.org/10.1080/19491034.2017.1313937 Text en © 2017 The Author(s). Published with license by Taylor & Francis. http://creativecommons.org/licenses/by/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Extra View Shinkai, Soya Nozaki, Tadasu Maeshima, Kazuhiro Togashi, Yuichi Bridging the dynamics and organization of chromatin domains by mathematical modeling |
title | Bridging the dynamics and organization of chromatin domains by mathematical modeling |
title_full | Bridging the dynamics and organization of chromatin domains by mathematical modeling |
title_fullStr | Bridging the dynamics and organization of chromatin domains by mathematical modeling |
title_full_unstemmed | Bridging the dynamics and organization of chromatin domains by mathematical modeling |
title_short | Bridging the dynamics and organization of chromatin domains by mathematical modeling |
title_sort | bridging the dynamics and organization of chromatin domains by mathematical modeling |
topic | Extra View |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5597300/ https://www.ncbi.nlm.nih.gov/pubmed/28406741 http://dx.doi.org/10.1080/19491034.2017.1313937 |
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