Cargando…
PAI-1 is a critical regulator of FGF23 homeostasis
Elevated levels of fibroblast growth factor 23 (FGF23), a bone-derived phosphaturic hormone, are associated with a number of pathologic conditions including chronic kidney disease, cardiac hypertrophy, and congestive heart failure. Currently, there are no specific treatments available to lower plasm...
Autores principales: | Eren, Mesut, Place, Aaron T., Thomas, Paul M., Flevaris, Panagiotis, Miyata, Toshio, Vaughan, Douglas E. |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Association for the Advancement of Science
2017
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5597312/ https://www.ncbi.nlm.nih.gov/pubmed/28924605 http://dx.doi.org/10.1126/sciadv.1603259 |
Ejemplares similares
-
A small molecule inhibitor of PAI-1 protects against doxorubicin-induced cellular senescence
por: Ghosh, Asish K., et al.
Publicado: (2016) -
OR22-6 Reversal Of Diet Induced Metabolic Syndrome In Mice With An Orally Active Small Molecule Inhibitor Of PAI-1
por: Levine, Joshua, et al.
Publicado: (2019) -
Role of PAI-1 in hepatic steatosis and dyslipidemia
por: Levine, Joshua A., et al.
Publicado: (2021) -
Pharmacological inhibition of PAI-1 alleviates cardiopulmonary pathologies induced by exposure to air pollutants PM(2.5)()
por: Ghosh, Asish K., et al.
Publicado: (2021) -
Structural Insight into the Two-Step Mechanism of PAI-1 Inhibition by Small Molecule TM5484
por: Sillen, Machteld, et al.
Publicado: (2021)