Cargando…

Manganese-induced trafficking and turnover of GPP130 is mediated by sortilin

Elevated, nontoxic doses of manganese (Mn) protect against Shiga toxin-1–induced cell death via down-regulation of GPP130, a cycling Golgi membrane protein that serves as an endosome-to-Golgi trafficking receptor for the toxin. Mn binds to GPP130 in the Golgi and causes GPP130 to oligomerize/aggrega...

Descripción completa

Detalles Bibliográficos
Autores principales: Venkat, Swati, Linstedt, Adam D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The American Society for Cell Biology 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5597328/
https://www.ncbi.nlm.nih.gov/pubmed/28768823
http://dx.doi.org/10.1091/mbc.E17-05-0326

Ejemplares similares