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Manganese-induced trafficking and turnover of GPP130 is mediated by sortilin

Elevated, nontoxic doses of manganese (Mn) protect against Shiga toxin-1–induced cell death via down-regulation of GPP130, a cycling Golgi membrane protein that serves as an endosome-to-Golgi trafficking receptor for the toxin. Mn binds to GPP130 in the Golgi and causes GPP130 to oligomerize/aggrega...

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Detalles Bibliográficos
Autores principales:	Venkat, Swati, Linstedt, Adam D.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The American Society for Cell Biology 2017
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5597328/ https://www.ncbi.nlm.nih.gov/pubmed/28768823 http://dx.doi.org/10.1091/mbc.E17-05-0326

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