Cargando…

Vδ2+ T cell response to malaria correlates with protection from infection but is attenuated with repeated exposure

Vδ2(+) γδ T cells are semi-innate T cells that expand markedly following P. falciparum (Pf) infection in naïve adults, but are lost and become dysfunctional among children repeatedly exposed to malaria. The role of these cells in mediating clinical immunity (i.e. protection against symptoms) to mala...

Descripción completa

Detalles Bibliográficos
Autores principales:	Jagannathan, Prasanna, Lutwama, Fredrick, Boyle, Michelle J., Nankya, Felistas, Farrington, Lila A., McIntyre, Tara I., Bowen, Katherine, Naluwu, Kate, Nalubega, Mayimuna, Musinguzi, Kenneth, Sikyomu, Esther, Budker, Rachel, Katureebe, Agaba, Rek, John, Greenhouse, Bryan, Dorsey, Grant, Kamya, Moses R., Feeney, Margaret E.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5597587/ https://www.ncbi.nlm.nih.gov/pubmed/28904345 http://dx.doi.org/10.1038/s41598-017-10624-3

Ejemplares similares

Opsonized antigen activates Vδ2+ T cells via CD16/FCγRIIIa in individuals with chronic malaria exposure
por: Farrington, Lila A., et al.
Publicado: (2020)

Exposure to pesticides in utero impacts the fetal immune system and response to vaccination in infancy
por: Prahl, Mary, et al.
Publicado: (2021)

Decline of FoxP3+ Regulatory CD4 T Cells in Peripheral Blood of Children Heavily Exposed to Malaria
por: Boyle, Michelle J., et al.
Publicado: (2015)

The Development of Plasmodium falciparum-Specific IL10 CD4 T Cells and Protection from Malaria in Children in an Area of High Malaria Transmission
por: Boyle, Michelle J., et al.
Publicado: (2017)

Sex Disparity in Cord Blood FoxP3(+) CD4 T Regulatory Cells in Infants Exposed to Malaria In Utero
por: Prahl, Mary, et al.
Publicado: (2017)

Timing of in utero malaria exposure influences fetal CD4 T cell regulatory versus effector differentiation
por: Prahl, Mary, et al.
Publicado: (2016)

Both inflammatory and regulatory cytokine responses to malaria are blunted with increasing age in highly exposed children
por: Farrington, Lila, et al.
Publicado: (2017)

Age-dependent changes in circulating Tfh cells influence development of functional malaria antibodies in children
por: Chan, Jo-Anne, et al.
Publicado: (2022)

FCRL5 Delineates Functionally Impaired Memory B Cells Associated with Plasmodium falciparum Exposure
por: Sullivan, Richard T., et al.
Publicado: (2015)

IFNγ/IL-10 Co-producing Cells Dominate the CD4 Response to Malaria in Highly Exposed Children
por: Jagannathan, Prasanna, et al.
Publicado: (2014)

Erratum to: B cell sub-types following acute malaria and associations with clinical immunity
por: Sullivan, Richard T., et al.
Publicado: (2016)

Characterizing microscopic and submicroscopic malaria parasitaemia at three sites with varied transmission intensity in Uganda
por: Rek, John, et al.
Publicado: (2016)

B cell sub-types following acute malaria and associations with clinical immunity
por: Sullivan, Richard T., et al.
Publicado: (2016)

Age-Related Changes in Malaria Clinical Phenotypes During Infancy Are Modified by Sickle Cell Trait
por: Zehner, Nicholas, et al.
Publicado: (2021)

Malaria-specific Type 1 regulatory T cells are more abundant in first pregnancies and associated with placental malaria
por: Kirosingh, Adam S., et al.
Publicado: (2023)

T-follicular helper cells in malaria infection and roles in antibody induction
por: Soon, Megan S F, et al.
Publicado: (2021)

In Utero Activation of Natural Killer Cells in Congenital Cytomegalovirus Infection
por: Vaaben, Anna V, et al.
Publicado: (2022)

Associations between red blood cell variants and malaria among children and adults from three areas of Uganda: a prospective cohort study
por: Kakande, Elijah, et al.
Publicado: (2020)

Mind the Gap: House Structure and the Risk of Malaria in Uganda
por: Wanzirah, Humphrey, et al.
Publicado: (2015)

Metagenomic next-generation sequencing to characterize potential etiologies of non-malarial fever in a cohort living in a high malaria burden area of Uganda
por: Mwakibete, Lusajo, et al.
Publicado: (2023)

B Cell Receptor Repertoire Analysis in Malaria-Naive and Malaria-Experienced Individuals Reveals Unique Characteristics of Atypical Memory B Cells
por: Braddom, Ashley E., et al.
Publicado: (2021)

Rapid improvements to rural Ugandan housing and their association with malaria from intense to reduced transmission: a cohort study
por: Rek, John C, et al.
Publicado: (2018)

Dihydroartemisinin-piperaquine for intermittent preventive treatment of malaria during pregnancy and risk of malaria in early childhood: A randomized controlled trial
por: Jagannathan, Prasanna, et al.
Publicado: (2018)

Quantification of anti-parasite and anti-disease immunity to malaria as a function of age and exposure
por: Rodriguez-Barraquer, Isabel, et al.
Publicado: (2018)

Increasing incidence of malaria in children despite insecticide-treated bed nets and prompt anti-malarial therapy in Tororo, Uganda
por: Jagannathan, Prasanna, et al.
Publicado: (2012)

Clinical consequences of submicroscopic malaria parasitaemia in Uganda
por: Katrak, Shereen, et al.
Publicado: (2018)

Reconstructing the SARS-CoV-2 epidemic in eastern Uganda through longitudinal serosurveillance in a malaria cohort
por: Briggs, Jessica, et al.
Publicado: (2022)

Seroprevalence of Antibodies to SARS-CoV-2 in Rural Households in Eastern Uganda, 2020-2022
por: Briggs, Jessica, et al.
Publicado: (2023)

Measures of Malaria Burden after Long-Lasting Insecticidal Net Distribution and Indoor Residual Spraying at Three Sites in Uganda: A Prospective Observational Study
por: Katureebe, Agaba, et al.
Publicado: (2016)

Sex-based differences in clearance of chronic Plasmodium falciparum infection
por: Briggs, Jessica, et al.
Publicado: (2020)

Measures of malaria transmission, infection, and disease in an area bordering two districts with and without sustained indoor residual spraying of insecticide in Uganda
por: Nankabirwa, Joaniter I., et al.
Publicado: (2022)

LLIN Evaluation in Uganda Project (LLINEUP): factors associated with ownership and use of long-lasting insecticidal nets in Uganda: a cross-sectional survey of 48 districts
por: Gonahasa, Samuel, et al.
Publicado: (2018)

LLIN Evaluation in Uganda Project (LLINEUP): a cross-sectional survey of species diversity and insecticide resistance in 48 districts of Uganda
por: Lynd, Amy, et al.
Publicado: (2019)

LLIN Evaluation in Uganda Project (LLINEUP): factors associated with childhood parasitaemia and anaemia 3 years after a national long-lasting insecticidal net distribution campaign: a cross-sectional survey
por: Rugnao, Sheila, et al.
Publicado: (2019)

Associations between urbanicity and malaria at local scales in Uganda
por: Kigozi, Simon P., et al.
Publicado: (2015)

Effect of long-lasting insecticidal nets with and without piperonyl butoxide on malaria indicators in Uganda (LLINEUP): a pragmatic, cluster-randomised trial embedded in a national LLIN distribution campaign
por: Staedke, Sarah G, et al.
Publicado: (2020)

Estimating the optimal interval between rounds of indoor residual spraying of insecticide using malaria incidence data from cohort studies
por: Mugenyi, Levicatus, et al.
Publicado: (2020)

House modifications as a malaria control tool: how does local context shape participants’ experience and interpretation in Uganda?
por: Kayendeke, Miriam, et al.
Publicado: (2023)

HLA Alleles B(*)53:01 and C(*)06:02 Are Associated With Higher Risk of P. falciparum Parasitemia in a Cohort in Uganda
por: Digitale, Jean C., et al.
Publicado: (2021)

Reductions in malaria in pregnancy and adverse birth outcomes following indoor residual spraying of insecticide in Uganda
por: Muhindo, Mary K., et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_a1varh2o2iaj9mjqovphft2ld1