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Polyphenols journey through blood-brain barrier towards neuronal protection
Age-related complications such as neurodegenerative disorders are increasing and remain cureless. The possibility of altering the progression or the development of these multifactorial diseases through diet is an emerging and attractive approach with increasing experimental support. We examined the...
Autores principales: | , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5597593/ https://www.ncbi.nlm.nih.gov/pubmed/28904352 http://dx.doi.org/10.1038/s41598-017-11512-6 |
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author | Figueira, I. Garcia, G. Pimpão, R. C. Terrasso, A. P. Costa, I. Almeida, A. F. Tavares, L. Pais, T. F. Pinto, P. Ventura, M. R. Filipe, A. McDougall, G. J. Stewart, D. Kim, K. S. Palmela, I. Brites, D. Brito, M. A. Brito, C. Santos, C. N. |
author_facet | Figueira, I. Garcia, G. Pimpão, R. C. Terrasso, A. P. Costa, I. Almeida, A. F. Tavares, L. Pais, T. F. Pinto, P. Ventura, M. R. Filipe, A. McDougall, G. J. Stewart, D. Kim, K. S. Palmela, I. Brites, D. Brito, M. A. Brito, C. Santos, C. N. |
author_sort | Figueira, I. |
collection | PubMed |
description | Age-related complications such as neurodegenerative disorders are increasing and remain cureless. The possibility of altering the progression or the development of these multifactorial diseases through diet is an emerging and attractive approach with increasing experimental support. We examined the potential of known bioavailable phenolic sulfates, arising from colonic metabolism of berries, to influence hallmarks of neurodegenerative processes. In silico predictions and in vitro transport studies across blood-brain barrier (BBB) endothelial cells, at circulating concentrations, provided evidence for differential transport, likely related to chemical structure. Moreover, endothelial metabolism of these phenolic sulfates produced a plethora of novel chemical entities with further potential bioactivies. Pre-conditioning with phenolic sulfates improved cellular responses to oxidative, excitotoxicity and inflammatory injuries and this attenuation of neuroinflammation was achieved via modulation of NF-κB pathway. Our results support the hypothesis that these small molecules, derived from dietary (poly)phenols may cross the BBB, reach brain cells, modulate microglia-mediated inflammation and exert neuroprotective effects, with potential for alleviation of neurodegenerative diseases. |
format | Online Article Text |
id | pubmed-5597593 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-55975932017-09-15 Polyphenols journey through blood-brain barrier towards neuronal protection Figueira, I. Garcia, G. Pimpão, R. C. Terrasso, A. P. Costa, I. Almeida, A. F. Tavares, L. Pais, T. F. Pinto, P. Ventura, M. R. Filipe, A. McDougall, G. J. Stewart, D. Kim, K. S. Palmela, I. Brites, D. Brito, M. A. Brito, C. Santos, C. N. Sci Rep Article Age-related complications such as neurodegenerative disorders are increasing and remain cureless. The possibility of altering the progression or the development of these multifactorial diseases through diet is an emerging and attractive approach with increasing experimental support. We examined the potential of known bioavailable phenolic sulfates, arising from colonic metabolism of berries, to influence hallmarks of neurodegenerative processes. In silico predictions and in vitro transport studies across blood-brain barrier (BBB) endothelial cells, at circulating concentrations, provided evidence for differential transport, likely related to chemical structure. Moreover, endothelial metabolism of these phenolic sulfates produced a plethora of novel chemical entities with further potential bioactivies. Pre-conditioning with phenolic sulfates improved cellular responses to oxidative, excitotoxicity and inflammatory injuries and this attenuation of neuroinflammation was achieved via modulation of NF-κB pathway. Our results support the hypothesis that these small molecules, derived from dietary (poly)phenols may cross the BBB, reach brain cells, modulate microglia-mediated inflammation and exert neuroprotective effects, with potential for alleviation of neurodegenerative diseases. Nature Publishing Group UK 2017-09-13 /pmc/articles/PMC5597593/ /pubmed/28904352 http://dx.doi.org/10.1038/s41598-017-11512-6 Text en © The Author(s) 2017, corrected publication 2021 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Article Figueira, I. Garcia, G. Pimpão, R. C. Terrasso, A. P. Costa, I. Almeida, A. F. Tavares, L. Pais, T. F. Pinto, P. Ventura, M. R. Filipe, A. McDougall, G. J. Stewart, D. Kim, K. S. Palmela, I. Brites, D. Brito, M. A. Brito, C. Santos, C. N. Polyphenols journey through blood-brain barrier towards neuronal protection |
title | Polyphenols journey through blood-brain barrier towards neuronal protection |
title_full | Polyphenols journey through blood-brain barrier towards neuronal protection |
title_fullStr | Polyphenols journey through blood-brain barrier towards neuronal protection |
title_full_unstemmed | Polyphenols journey through blood-brain barrier towards neuronal protection |
title_short | Polyphenols journey through blood-brain barrier towards neuronal protection |
title_sort | polyphenols journey through blood-brain barrier towards neuronal protection |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5597593/ https://www.ncbi.nlm.nih.gov/pubmed/28904352 http://dx.doi.org/10.1038/s41598-017-11512-6 |
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