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Calcitriol reduces kidney development disorders in rats provoked by losartan administration during lactation

Calcitriol has important effects on cellular differentiation and proliferation, as well as on the regulation of the renin gene. Disturbances in renal development can be observed in rats exposed to angiotensin II (AngII) antagonists during lactation period. The lack of tubular differentiation in losa...

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Autores principales: de Almeida, Lucas Ferreira, Francescato, Heloísa Della Coletta, da Silva, Cleonice Giovanini Alves, Costa, Roberto Silva, Coimbra, Terezila Machado
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5597607/
https://www.ncbi.nlm.nih.gov/pubmed/28904363
http://dx.doi.org/10.1038/s41598-017-11815-8
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author de Almeida, Lucas Ferreira
Francescato, Heloísa Della Coletta
da Silva, Cleonice Giovanini Alves
Costa, Roberto Silva
Coimbra, Terezila Machado
author_facet de Almeida, Lucas Ferreira
Francescato, Heloísa Della Coletta
da Silva, Cleonice Giovanini Alves
Costa, Roberto Silva
Coimbra, Terezila Machado
author_sort de Almeida, Lucas Ferreira
collection PubMed
description Calcitriol has important effects on cellular differentiation and proliferation, as well as on the regulation of the renin gene. Disturbances in renal development can be observed in rats exposed to angiotensin II (AngII) antagonists during lactation period. The lack of tubular differentiation in losartan-treated rats can affect calcitriol uptake. This study evaluated the effect of calcitriol administration in renal development disturbances in rats provoked by losartan (AngII type 1 receptor antagonist) administration during lactation. Animals exposed to losartan presented higher albuminuria, systolic blood pressure, increased sodium and potassium fractional excretion, and decreased glomerular filtration rate compared to controls. These animals also showed a decreased glomerular area and a higher interstitial relative area from the renal cortex, with increased expression of fibronectin, alpha-SM-actin, vimentin, and p-JNK; and an increased number of macrophages, p-p38, PCNA and decreased cubilin expression. Increased urinary excretion of MCP-1 and TGF-β was also observed. All these alterations were less intense in the losartan + calcitriol group.The animals treated with calcitriol showed an improvement in cellular differentiation, and in renal function and structure. This effect was associated with reduction of cell proliferation and inflammation.
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spelling pubmed-55976072017-09-15 Calcitriol reduces kidney development disorders in rats provoked by losartan administration during lactation de Almeida, Lucas Ferreira Francescato, Heloísa Della Coletta da Silva, Cleonice Giovanini Alves Costa, Roberto Silva Coimbra, Terezila Machado Sci Rep Article Calcitriol has important effects on cellular differentiation and proliferation, as well as on the regulation of the renin gene. Disturbances in renal development can be observed in rats exposed to angiotensin II (AngII) antagonists during lactation period. The lack of tubular differentiation in losartan-treated rats can affect calcitriol uptake. This study evaluated the effect of calcitriol administration in renal development disturbances in rats provoked by losartan (AngII type 1 receptor antagonist) administration during lactation. Animals exposed to losartan presented higher albuminuria, systolic blood pressure, increased sodium and potassium fractional excretion, and decreased glomerular filtration rate compared to controls. These animals also showed a decreased glomerular area and a higher interstitial relative area from the renal cortex, with increased expression of fibronectin, alpha-SM-actin, vimentin, and p-JNK; and an increased number of macrophages, p-p38, PCNA and decreased cubilin expression. Increased urinary excretion of MCP-1 and TGF-β was also observed. All these alterations were less intense in the losartan + calcitriol group.The animals treated with calcitriol showed an improvement in cellular differentiation, and in renal function and structure. This effect was associated with reduction of cell proliferation and inflammation. Nature Publishing Group UK 2017-09-13 /pmc/articles/PMC5597607/ /pubmed/28904363 http://dx.doi.org/10.1038/s41598-017-11815-8 Text en © The Author(s) 2017 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
de Almeida, Lucas Ferreira
Francescato, Heloísa Della Coletta
da Silva, Cleonice Giovanini Alves
Costa, Roberto Silva
Coimbra, Terezila Machado
Calcitriol reduces kidney development disorders in rats provoked by losartan administration during lactation
title Calcitriol reduces kidney development disorders in rats provoked by losartan administration during lactation
title_full Calcitriol reduces kidney development disorders in rats provoked by losartan administration during lactation
title_fullStr Calcitriol reduces kidney development disorders in rats provoked by losartan administration during lactation
title_full_unstemmed Calcitriol reduces kidney development disorders in rats provoked by losartan administration during lactation
title_short Calcitriol reduces kidney development disorders in rats provoked by losartan administration during lactation
title_sort calcitriol reduces kidney development disorders in rats provoked by losartan administration during lactation
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5597607/
https://www.ncbi.nlm.nih.gov/pubmed/28904363
http://dx.doi.org/10.1038/s41598-017-11815-8
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