Identification of sites of 2′-O-methylation vulnerability in human ribosomal RNAs by systematic mapping

Ribosomal RNA modifications are important in optimizing ribosome function. Sugar 2′-O-methylation performed by fibrillarin-associated box C/D antisense guide snoRNAs impacts all steps of translation, playing a role in disease etiology (cancer). As it renders adjacent phosphodiester bonds resistant t...

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Detalles Bibliográficos
Autores principales: Sharma, Sunny, Marchand, Virginie, Motorin, Yuri, Lafontaine, Denis L. J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5597630/
https://www.ncbi.nlm.nih.gov/pubmed/28904332
http://dx.doi.org/10.1038/s41598-017-09734-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5597630/
https://www.ncbi.nlm.nih.gov/pubmed/28904332
http://dx.doi.org/10.1038/s41598-017-09734-9

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