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Identification of sites of 2′-O-methylation vulnerability in human ribosomal RNAs by systematic mapping

Ribosomal RNA modifications are important in optimizing ribosome function. Sugar 2′-O-methylation performed by fibrillarin-associated box C/D antisense guide snoRNAs impacts all steps of translation, playing a role in disease etiology (cancer). As it renders adjacent phosphodiester bonds resistant t...

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Detalles Bibliográficos
Autores principales:	Sharma, Sunny, Marchand, Virginie, Motorin, Yuri, Lafontaine, Denis L. J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5597630/ https://www.ncbi.nlm.nih.gov/pubmed/28904332 http://dx.doi.org/10.1038/s41598-017-09734-9

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