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Plasma Cell Cheilitis: A Clinicopathological and Immunohistochemical Study of 13 Cases

BACKGROUND: Plasma cell cheilitis is an unusual benign plasma cell proliferative disease of an unknown etiology that typically presents on the lip. OBJECTIVE: The aim of this study was to investigate the clinicopathological characteristics of 13 cases of plasma cell cheilitis. METHODS: The present s...

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Autores principales: Lee, Jin Yong, Kim, Kwang Ho, Hahm, Ji Eun, Ha, Jae Won, Kwon, Won Joo, Kim, Chul Woo, Kim, Sang Seok
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Korean Dermatological Association; The Korean Society for Investigative Dermatology 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5597645/
https://www.ncbi.nlm.nih.gov/pubmed/28966508
http://dx.doi.org/10.5021/ad.2017.29.5.536
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author Lee, Jin Yong
Kim, Kwang Ho
Hahm, Ji Eun
Ha, Jae Won
Kwon, Won Joo
Kim, Chul Woo
Kim, Sang Seok
author_facet Lee, Jin Yong
Kim, Kwang Ho
Hahm, Ji Eun
Ha, Jae Won
Kwon, Won Joo
Kim, Chul Woo
Kim, Sang Seok
author_sort Lee, Jin Yong
collection PubMed
description BACKGROUND: Plasma cell cheilitis is an unusual benign plasma cell proliferative disease of an unknown etiology that typically presents on the lip. OBJECTIVE: The aim of this study was to investigate the clinicopathological characteristics of 13 cases of plasma cell cheilitis. METHODS: The present study investigated the clinical manifestations, treatment modalities, and outcome of 13 patients diagnosed with plasma cell cheilitis from 2011 to 2016 at Kangdong Sacred Heart Hospital and Hallym University Sacred Heart Hospital. Biopsy specimens of the all cases were evaluated using conventional hematoxylin and eosin staining with kappa and lambda immunoglobulin light chain immunohistochemistry. RESULTS: The age of the patients ranged from 39 to 86 years (mean, 64.7 years), with male predominance. Histopathologically, 61.5% and 38.5% of patients showed band-like and pan dermal plasmacytic infiltrates, respectively. Eosinophilic infiltration was noted in 69.2% of patients. All cases showed both kappa and lambda immunoglobulin light chain reactivities, and kappa predominance was confirmed in 9 patients (69.2%). A majority of the patients was treated with local therapy, such as intralesional steroid injection with topical tacrolimus. Among the 13 patients, plasma cell cheilitis completely resolved, partially resolved, and recurred in 3 (23.1%), 5 (38.5%), and 5 patients (38.5%), respectively. CONCLUSION: Plasma cell cheilitis presented as erosive edematous circumscribed patches or plaques affecting mainly the lower lip of elderly male patients. The majority of histopathology cases showed characteristic plasma cell aggregation on the upper dermis that was immunopositive for immunoglobulin light chain, with kappa predominance.
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spelling pubmed-55976452017-10-01 Plasma Cell Cheilitis: A Clinicopathological and Immunohistochemical Study of 13 Cases Lee, Jin Yong Kim, Kwang Ho Hahm, Ji Eun Ha, Jae Won Kwon, Won Joo Kim, Chul Woo Kim, Sang Seok Ann Dermatol Original Article BACKGROUND: Plasma cell cheilitis is an unusual benign plasma cell proliferative disease of an unknown etiology that typically presents on the lip. OBJECTIVE: The aim of this study was to investigate the clinicopathological characteristics of 13 cases of plasma cell cheilitis. METHODS: The present study investigated the clinical manifestations, treatment modalities, and outcome of 13 patients diagnosed with plasma cell cheilitis from 2011 to 2016 at Kangdong Sacred Heart Hospital and Hallym University Sacred Heart Hospital. Biopsy specimens of the all cases were evaluated using conventional hematoxylin and eosin staining with kappa and lambda immunoglobulin light chain immunohistochemistry. RESULTS: The age of the patients ranged from 39 to 86 years (mean, 64.7 years), with male predominance. Histopathologically, 61.5% and 38.5% of patients showed band-like and pan dermal plasmacytic infiltrates, respectively. Eosinophilic infiltration was noted in 69.2% of patients. All cases showed both kappa and lambda immunoglobulin light chain reactivities, and kappa predominance was confirmed in 9 patients (69.2%). A majority of the patients was treated with local therapy, such as intralesional steroid injection with topical tacrolimus. Among the 13 patients, plasma cell cheilitis completely resolved, partially resolved, and recurred in 3 (23.1%), 5 (38.5%), and 5 patients (38.5%), respectively. CONCLUSION: Plasma cell cheilitis presented as erosive edematous circumscribed patches or plaques affecting mainly the lower lip of elderly male patients. The majority of histopathology cases showed characteristic plasma cell aggregation on the upper dermis that was immunopositive for immunoglobulin light chain, with kappa predominance. The Korean Dermatological Association; The Korean Society for Investigative Dermatology 2017-10 2017-08-25 /pmc/articles/PMC5597645/ /pubmed/28966508 http://dx.doi.org/10.5021/ad.2017.29.5.536 Text en Copyright © 2017 The Korean Dermatological Association and The Korean Society for Investigative Dermatology http://creativecommons.org/licenses/by-nc/4.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Lee, Jin Yong
Kim, Kwang Ho
Hahm, Ji Eun
Ha, Jae Won
Kwon, Won Joo
Kim, Chul Woo
Kim, Sang Seok
Plasma Cell Cheilitis: A Clinicopathological and Immunohistochemical Study of 13 Cases
title Plasma Cell Cheilitis: A Clinicopathological and Immunohistochemical Study of 13 Cases
title_full Plasma Cell Cheilitis: A Clinicopathological and Immunohistochemical Study of 13 Cases
title_fullStr Plasma Cell Cheilitis: A Clinicopathological and Immunohistochemical Study of 13 Cases
title_full_unstemmed Plasma Cell Cheilitis: A Clinicopathological and Immunohistochemical Study of 13 Cases
title_short Plasma Cell Cheilitis: A Clinicopathological and Immunohistochemical Study of 13 Cases
title_sort plasma cell cheilitis: a clinicopathological and immunohistochemical study of 13 cases
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5597645/
https://www.ncbi.nlm.nih.gov/pubmed/28966508
http://dx.doi.org/10.5021/ad.2017.29.5.536
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