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Histiocytoid Sweet Syndrome in a Child without Underlying Systemic Disease

Sweet syndrome (acute, febrile, neutrophilic dermatosis) is characterized by the acute onset of an eruption of painful nodules or erythematous or violaceous plaques on the limbs, face and neck. These symptoms are accompanied by fever. The diagnostic features include histopathological findings of der...

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Autores principales: Yeom, Seung Dohn, Ko, Hye Soo, Moon, Jong Hyuk, Kang, Min Ji, Byun, Ji Won, Choi, Gwang Seong, Shin, Jeonghyun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Korean Dermatological Association; The Korean Society for Investigative Dermatology 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5597659/
https://www.ncbi.nlm.nih.gov/pubmed/28966522
http://dx.doi.org/10.5021/ad.2017.29.5.626
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author Yeom, Seung Dohn
Ko, Hye Soo
Moon, Jong Hyuk
Kang, Min Ji
Byun, Ji Won
Choi, Gwang Seong
Shin, Jeonghyun
author_facet Yeom, Seung Dohn
Ko, Hye Soo
Moon, Jong Hyuk
Kang, Min Ji
Byun, Ji Won
Choi, Gwang Seong
Shin, Jeonghyun
author_sort Yeom, Seung Dohn
collection PubMed
description Sweet syndrome (acute, febrile, neutrophilic dermatosis) is characterized by the acute onset of an eruption of painful nodules or erythematous or violaceous plaques on the limbs, face and neck. These symptoms are accompanied by fever. The diagnostic features include histopathological findings of dermal neutrophilic infiltration without leukocytoclastic vasculitis or peripheral blood leukocytosis. Sweet syndrome is associated with infection, malignancies, autoimmune disease, pregnancy, and drugs. Patients with Sweet syndrome demonstrate a complete and rapid response to systemic steroid administration. Recently, a distinct variant of Sweet syndrome was reported, termed “histiocytoid Sweet syndrome”, in which the infiltration of myeloperoxidase-positive histiocytoid mononuclear cells are observed (in contrast to the infiltration of neutrophils). The other clinical features are similar to those of classic Sweet syndrome. Pediatric Sweet syndrome is uncommon, and the histiocytoid type is even rarer. To date, four cases of histiocytoid Sweet syndrome have been reported in children. Herein, we describe a case of histiocytoid Sweet syndrome in an otherwise healthy 10-year-old boy with no underlying systemic disease in whom non-steroidal, anti-inflammatory drug treatment was successful.
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spelling pubmed-55976592017-10-01 Histiocytoid Sweet Syndrome in a Child without Underlying Systemic Disease Yeom, Seung Dohn Ko, Hye Soo Moon, Jong Hyuk Kang, Min Ji Byun, Ji Won Choi, Gwang Seong Shin, Jeonghyun Ann Dermatol Case Report Sweet syndrome (acute, febrile, neutrophilic dermatosis) is characterized by the acute onset of an eruption of painful nodules or erythematous or violaceous plaques on the limbs, face and neck. These symptoms are accompanied by fever. The diagnostic features include histopathological findings of dermal neutrophilic infiltration without leukocytoclastic vasculitis or peripheral blood leukocytosis. Sweet syndrome is associated with infection, malignancies, autoimmune disease, pregnancy, and drugs. Patients with Sweet syndrome demonstrate a complete and rapid response to systemic steroid administration. Recently, a distinct variant of Sweet syndrome was reported, termed “histiocytoid Sweet syndrome”, in which the infiltration of myeloperoxidase-positive histiocytoid mononuclear cells are observed (in contrast to the infiltration of neutrophils). The other clinical features are similar to those of classic Sweet syndrome. Pediatric Sweet syndrome is uncommon, and the histiocytoid type is even rarer. To date, four cases of histiocytoid Sweet syndrome have been reported in children. Herein, we describe a case of histiocytoid Sweet syndrome in an otherwise healthy 10-year-old boy with no underlying systemic disease in whom non-steroidal, anti-inflammatory drug treatment was successful. The Korean Dermatological Association; The Korean Society for Investigative Dermatology 2017-10 2017-08-25 /pmc/articles/PMC5597659/ /pubmed/28966522 http://dx.doi.org/10.5021/ad.2017.29.5.626 Text en Copyright © 2017 The Korean Dermatological Association and The Korean Society for Investigative Dermatology http://creativecommons.org/licenses/by-nc/4.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Yeom, Seung Dohn
Ko, Hye Soo
Moon, Jong Hyuk
Kang, Min Ji
Byun, Ji Won
Choi, Gwang Seong
Shin, Jeonghyun
Histiocytoid Sweet Syndrome in a Child without Underlying Systemic Disease
title Histiocytoid Sweet Syndrome in a Child without Underlying Systemic Disease
title_full Histiocytoid Sweet Syndrome in a Child without Underlying Systemic Disease
title_fullStr Histiocytoid Sweet Syndrome in a Child without Underlying Systemic Disease
title_full_unstemmed Histiocytoid Sweet Syndrome in a Child without Underlying Systemic Disease
title_short Histiocytoid Sweet Syndrome in a Child without Underlying Systemic Disease
title_sort histiocytoid sweet syndrome in a child without underlying systemic disease
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5597659/
https://www.ncbi.nlm.nih.gov/pubmed/28966522
http://dx.doi.org/10.5021/ad.2017.29.5.626
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