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The pearl oyster Pinctada fucata martensii genome and multi-omic analyses provide insights into biomineralization

Nacre, the iridescent material found in pearls and shells of molluscs, is formed through an extraordinary process of matrix-assisted biomineralization. Despite recent advances, many aspects of the biomineralization process and its evolutionary origin remain unknown. The pearl oyster Pinctada fucata...

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Autores principales: Du, Xiaodong, Fan, Guangyi, Jiao, Yu, Zhang, He, Guo, Ximing, Huang, Ronglian, Zheng, Zhe, Bian, Chao, Deng, Yuewen, Wang, Qingheng, Wang, Zhongduo, Liang, Xinming, Liang, Haiying, Shi, Chengcheng, Zhao, Xiaoxia, Sun, Fengming, Hao, Ruijuan, Bai, Jie, Liu, Jialiang, Chen, Wenbin, Liang, Jinlian, Liu, Weiqing, Xu, Zhe, Shi, Qiong, Xu, Xun, Zhang, Guofan, Liu, Xin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5597905/
https://www.ncbi.nlm.nih.gov/pubmed/28873964
http://dx.doi.org/10.1093/gigascience/gix059
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author Du, Xiaodong
Fan, Guangyi
Jiao, Yu
Zhang, He
Guo, Ximing
Huang, Ronglian
Zheng, Zhe
Bian, Chao
Deng, Yuewen
Wang, Qingheng
Wang, Zhongduo
Liang, Xinming
Liang, Haiying
Shi, Chengcheng
Zhao, Xiaoxia
Sun, Fengming
Hao, Ruijuan
Bai, Jie
Liu, Jialiang
Chen, Wenbin
Liang, Jinlian
Liu, Weiqing
Xu, Zhe
Shi, Qiong
Xu, Xun
Zhang, Guofan
Liu, Xin
author_facet Du, Xiaodong
Fan, Guangyi
Jiao, Yu
Zhang, He
Guo, Ximing
Huang, Ronglian
Zheng, Zhe
Bian, Chao
Deng, Yuewen
Wang, Qingheng
Wang, Zhongduo
Liang, Xinming
Liang, Haiying
Shi, Chengcheng
Zhao, Xiaoxia
Sun, Fengming
Hao, Ruijuan
Bai, Jie
Liu, Jialiang
Chen, Wenbin
Liang, Jinlian
Liu, Weiqing
Xu, Zhe
Shi, Qiong
Xu, Xun
Zhang, Guofan
Liu, Xin
author_sort Du, Xiaodong
collection PubMed
description Nacre, the iridescent material found in pearls and shells of molluscs, is formed through an extraordinary process of matrix-assisted biomineralization. Despite recent advances, many aspects of the biomineralization process and its evolutionary origin remain unknown. The pearl oyster Pinctada fucata martensii is a well-known master of biomineralization, but the molecular mechanisms that underlie its production of shells and pearls are not fully understood. We sequenced the highly polymorphic genome of the pearl oyster and conducted multi-omic and biochemical studies to probe nacre formation. We identified a large set of novel proteins participating in matrix-framework formation, many in expanded families, including components similar to that found in vertebrate bones such as collagen-related VWA-containing proteins, chondroitin sulfotransferases, and regulatory elements. Considering that there are only collagen-based matrices in vertebrate bones and chitin-based matrices in most invertebrate skeletons, the presence of both chitin and elements of collagen-based matrices in nacre suggests that elements of chitin- and collagen-based matrices have deep roots and might be part of an ancient biomineralizing matrix. Our results expand the current shell matrix-framework model and provide new insights into the evolution of diverse biomineralization systems.
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spelling pubmed-55979052017-09-19 The pearl oyster Pinctada fucata martensii genome and multi-omic analyses provide insights into biomineralization Du, Xiaodong Fan, Guangyi Jiao, Yu Zhang, He Guo, Ximing Huang, Ronglian Zheng, Zhe Bian, Chao Deng, Yuewen Wang, Qingheng Wang, Zhongduo Liang, Xinming Liang, Haiying Shi, Chengcheng Zhao, Xiaoxia Sun, Fengming Hao, Ruijuan Bai, Jie Liu, Jialiang Chen, Wenbin Liang, Jinlian Liu, Weiqing Xu, Zhe Shi, Qiong Xu, Xun Zhang, Guofan Liu, Xin Gigascience Research Nacre, the iridescent material found in pearls and shells of molluscs, is formed through an extraordinary process of matrix-assisted biomineralization. Despite recent advances, many aspects of the biomineralization process and its evolutionary origin remain unknown. The pearl oyster Pinctada fucata martensii is a well-known master of biomineralization, but the molecular mechanisms that underlie its production of shells and pearls are not fully understood. We sequenced the highly polymorphic genome of the pearl oyster and conducted multi-omic and biochemical studies to probe nacre formation. We identified a large set of novel proteins participating in matrix-framework formation, many in expanded families, including components similar to that found in vertebrate bones such as collagen-related VWA-containing proteins, chondroitin sulfotransferases, and regulatory elements. Considering that there are only collagen-based matrices in vertebrate bones and chitin-based matrices in most invertebrate skeletons, the presence of both chitin and elements of collagen-based matrices in nacre suggests that elements of chitin- and collagen-based matrices have deep roots and might be part of an ancient biomineralizing matrix. Our results expand the current shell matrix-framework model and provide new insights into the evolution of diverse biomineralization systems. Oxford University Press 2017-07-25 /pmc/articles/PMC5597905/ /pubmed/28873964 http://dx.doi.org/10.1093/gigascience/gix059 Text en © The Authors 2017. Published by Oxford University Press. http://creativecommons.org/licenses/by/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research
Du, Xiaodong
Fan, Guangyi
Jiao, Yu
Zhang, He
Guo, Ximing
Huang, Ronglian
Zheng, Zhe
Bian, Chao
Deng, Yuewen
Wang, Qingheng
Wang, Zhongduo
Liang, Xinming
Liang, Haiying
Shi, Chengcheng
Zhao, Xiaoxia
Sun, Fengming
Hao, Ruijuan
Bai, Jie
Liu, Jialiang
Chen, Wenbin
Liang, Jinlian
Liu, Weiqing
Xu, Zhe
Shi, Qiong
Xu, Xun
Zhang, Guofan
Liu, Xin
The pearl oyster Pinctada fucata martensii genome and multi-omic analyses provide insights into biomineralization
title The pearl oyster Pinctada fucata martensii genome and multi-omic analyses provide insights into biomineralization
title_full The pearl oyster Pinctada fucata martensii genome and multi-omic analyses provide insights into biomineralization
title_fullStr The pearl oyster Pinctada fucata martensii genome and multi-omic analyses provide insights into biomineralization
title_full_unstemmed The pearl oyster Pinctada fucata martensii genome and multi-omic analyses provide insights into biomineralization
title_short The pearl oyster Pinctada fucata martensii genome and multi-omic analyses provide insights into biomineralization
title_sort pearl oyster pinctada fucata martensii genome and multi-omic analyses provide insights into biomineralization
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5597905/
https://www.ncbi.nlm.nih.gov/pubmed/28873964
http://dx.doi.org/10.1093/gigascience/gix059
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