A case of pernicious anemia requiring differential diagnosis of autoimmune hemolytic anemia complication

An 80-year-old female was admitted to our hospital due to malaise. The initial diagnosis on admission was pernicious anemia (PA), Hashimoto thyroiditis and autoimmune atrophic gastritis. Autoimmune hemolytic anemia was suspected because direct antiglobulin test (DAT) was positive. Treatment with vit...

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Autores principales: Todo, Saki, Okamoto, Kohei, Sugimoto, Takeshi, Takahashi, Toshimasa, Nakagawa, Yasushi, Arai, Takashi, Nishiyama, Katsuhito, Hara, Kenta, Yasutomo, Yoshiro, Yokono, Koichi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2017
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5597912/
https://www.ncbi.nlm.nih.gov/pubmed/28948030
http://dx.doi.org/10.1093/omcr/omx053
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author Todo, Saki
Okamoto, Kohei
Sugimoto, Takeshi
Takahashi, Toshimasa
Nakagawa, Yasushi
Arai, Takashi
Nishiyama, Katsuhito
Hara, Kenta
Yasutomo, Yoshiro
Yokono, Koichi
author_facet Todo, Saki
Okamoto, Kohei
Sugimoto, Takeshi
Takahashi, Toshimasa
Nakagawa, Yasushi
Arai, Takashi
Nishiyama, Katsuhito
Hara, Kenta
Yasutomo, Yoshiro
Yokono, Koichi
author_sort Todo, Saki
collection PubMed
description An 80-year-old female was admitted to our hospital due to malaise. The initial diagnosis on admission was pernicious anemia (PA), Hashimoto thyroiditis and autoimmune atrophic gastritis. Autoimmune hemolytic anemia was suspected because direct antiglobulin test (DAT) was positive. Treatment with vitamin B12 improved anemia, with the disappearance of hemolysis. In some cases, PA patients with positive DAT may have hemolysis without the involvement of the autoimmune mechanism. Therefore, it is important to carefully assess PA patients with hemolysis and positive DAT for the prevention of unnecessary administration of steroid therapy.
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spelling pubmed-55979122017-09-25 A case of pernicious anemia requiring differential diagnosis of autoimmune hemolytic anemia complication Todo, Saki Okamoto, Kohei Sugimoto, Takeshi Takahashi, Toshimasa Nakagawa, Yasushi Arai, Takashi Nishiyama, Katsuhito Hara, Kenta Yasutomo, Yoshiro Yokono, Koichi Oxf Med Case Reports Case Report An 80-year-old female was admitted to our hospital due to malaise. The initial diagnosis on admission was pernicious anemia (PA), Hashimoto thyroiditis and autoimmune atrophic gastritis. Autoimmune hemolytic anemia was suspected because direct antiglobulin test (DAT) was positive. Treatment with vitamin B12 improved anemia, with the disappearance of hemolysis. In some cases, PA patients with positive DAT may have hemolysis without the involvement of the autoimmune mechanism. Therefore, it is important to carefully assess PA patients with hemolysis and positive DAT for the prevention of unnecessary administration of steroid therapy. Oxford University Press 2017-09-04 /pmc/articles/PMC5597912/ /pubmed/28948030 http://dx.doi.org/10.1093/omcr/omx053 Text en © The Author 2017. Published by Oxford University Press. http://creativecommons.org/licenses/by-nc/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
spellingShingle Case Report
Todo, Saki
Okamoto, Kohei
Sugimoto, Takeshi
Takahashi, Toshimasa
Nakagawa, Yasushi
Arai, Takashi
Nishiyama, Katsuhito
Hara, Kenta
Yasutomo, Yoshiro
Yokono, Koichi
A case of pernicious anemia requiring differential diagnosis of autoimmune hemolytic anemia complication
title A case of pernicious anemia requiring differential diagnosis of autoimmune hemolytic anemia complication
title_full A case of pernicious anemia requiring differential diagnosis of autoimmune hemolytic anemia complication
title_fullStr A case of pernicious anemia requiring differential diagnosis of autoimmune hemolytic anemia complication
title_full_unstemmed A case of pernicious anemia requiring differential diagnosis of autoimmune hemolytic anemia complication
title_short A case of pernicious anemia requiring differential diagnosis of autoimmune hemolytic anemia complication
title_sort case of pernicious anemia requiring differential diagnosis of autoimmune hemolytic anemia complication
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5597912/
https://www.ncbi.nlm.nih.gov/pubmed/28948030
http://dx.doi.org/10.1093/omcr/omx053
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