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SSTR4, Childhood Adversity, Self-efficacy and Suicide Risk in Alcoholics

BACKGROUND: Patients with alcohol dependence (AD) are known to develop poor social skills, to report a higher number of adverse childhood experiences (ACEs) and to attempt suicide more frequently than the general population. The background for the association between ACEs and a higher risk of suicid...

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Autores principales: Berent, Dominika, Emilien, Gerard, Podgórski, Michał, Kusideł, Ewa, Kulczycka-Wojdala, Dominika, Szymańska, Bożena, Macander, Marian, Pawłowska, Zofia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: De Gruyter Open 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5597949/
https://www.ncbi.nlm.nih.gov/pubmed/28924491
http://dx.doi.org/10.1515/tnsci-2017-0013
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author Berent, Dominika
Emilien, Gerard
Podgórski, Michał
Kusideł, Ewa
Kulczycka-Wojdala, Dominika
Szymańska, Bożena
Macander, Marian
Pawłowska, Zofia
author_facet Berent, Dominika
Emilien, Gerard
Podgórski, Michał
Kusideł, Ewa
Kulczycka-Wojdala, Dominika
Szymańska, Bożena
Macander, Marian
Pawłowska, Zofia
author_sort Berent, Dominika
collection PubMed
description BACKGROUND: Patients with alcohol dependence (AD) are known to develop poor social skills, to report a higher number of adverse childhood experiences (ACEs) and to attempt suicide more frequently than the general population. The background for the association between ACEs and a higher risk of suicide still remains understudied. SSTR4 rs2567608 is a functional polymorphism of the gene for somatostatin receptor subtype 4, predominantly found in the CA1 hippocampus area and involved in memory formation. We hypothesize that the functional polymorphism SSTR4 rs2567608, general self-efficacy, and adverse childhood experiences influence the risk of suicide attempt in patients with AD. METHODOLOGY: 176 patients with AD and 127 healthy controls were interviewed regarding 13 categories of ACEs and assessed with the General Self-Efficacy Scale. Genotyping for the SSTR4 rs2567608 polymorphism was performed according to the manufacturer’s standard PCR protocol. RESULTS: Patients with AD and the controls did not differ significantly according to the SSTR4 rs2567608 genotype and allele frequencies. Lower general self-efficacy, higher number of ACEs, and the SSTR4 rs2567608 TT genotype increased the risk of suicide attempt in patients with AD, and it persisted significant only in male patients with AD. CONCLUSIONS: Our study supports previous findings on ACEs and general self-efficacy association with a risk for suicide. Additionally, we suggest that patients with AD of the SSTR4 rs2567608 TT genotype may be more vulnerable to ACEs and at a higher risk of suicide attempt.
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spelling pubmed-55979492017-09-18 SSTR4, Childhood Adversity, Self-efficacy and Suicide Risk in Alcoholics Berent, Dominika Emilien, Gerard Podgórski, Michał Kusideł, Ewa Kulczycka-Wojdala, Dominika Szymańska, Bożena Macander, Marian Pawłowska, Zofia Transl Neurosci Regular Articles BACKGROUND: Patients with alcohol dependence (AD) are known to develop poor social skills, to report a higher number of adverse childhood experiences (ACEs) and to attempt suicide more frequently than the general population. The background for the association between ACEs and a higher risk of suicide still remains understudied. SSTR4 rs2567608 is a functional polymorphism of the gene for somatostatin receptor subtype 4, predominantly found in the CA1 hippocampus area and involved in memory formation. We hypothesize that the functional polymorphism SSTR4 rs2567608, general self-efficacy, and adverse childhood experiences influence the risk of suicide attempt in patients with AD. METHODOLOGY: 176 patients with AD and 127 healthy controls were interviewed regarding 13 categories of ACEs and assessed with the General Self-Efficacy Scale. Genotyping for the SSTR4 rs2567608 polymorphism was performed according to the manufacturer’s standard PCR protocol. RESULTS: Patients with AD and the controls did not differ significantly according to the SSTR4 rs2567608 genotype and allele frequencies. Lower general self-efficacy, higher number of ACEs, and the SSTR4 rs2567608 TT genotype increased the risk of suicide attempt in patients with AD, and it persisted significant only in male patients with AD. CONCLUSIONS: Our study supports previous findings on ACEs and general self-efficacy association with a risk for suicide. Additionally, we suggest that patients with AD of the SSTR4 rs2567608 TT genotype may be more vulnerable to ACEs and at a higher risk of suicide attempt. De Gruyter Open 2017-09-14 /pmc/articles/PMC5597949/ /pubmed/28924491 http://dx.doi.org/10.1515/tnsci-2017-0013 Text en © 2017 Dominika Berent et al. http://creativecommons.org/licenses/by-nc-nd/3.0 This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.
spellingShingle Regular Articles
Berent, Dominika
Emilien, Gerard
Podgórski, Michał
Kusideł, Ewa
Kulczycka-Wojdala, Dominika
Szymańska, Bożena
Macander, Marian
Pawłowska, Zofia
SSTR4, Childhood Adversity, Self-efficacy and Suicide Risk in Alcoholics
title SSTR4, Childhood Adversity, Self-efficacy and Suicide Risk in Alcoholics
title_full SSTR4, Childhood Adversity, Self-efficacy and Suicide Risk in Alcoholics
title_fullStr SSTR4, Childhood Adversity, Self-efficacy and Suicide Risk in Alcoholics
title_full_unstemmed SSTR4, Childhood Adversity, Self-efficacy and Suicide Risk in Alcoholics
title_short SSTR4, Childhood Adversity, Self-efficacy and Suicide Risk in Alcoholics
title_sort sstr4, childhood adversity, self-efficacy and suicide risk in alcoholics
topic Regular Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5597949/
https://www.ncbi.nlm.nih.gov/pubmed/28924491
http://dx.doi.org/10.1515/tnsci-2017-0013
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