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The Essentials of a Global Index for Cognitive Function
Cognition is comprised of the faculties: perception, creativity, intuition, and ratiocination. Optimal levels of cognition are needed for independent functioning and balanced living. With an aging population that continues to grow, dietary supplements that tilt the balance towards maintenance of cog...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
De Gruyter Open
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5597950/ https://www.ncbi.nlm.nih.gov/pubmed/28924492 http://dx.doi.org/10.1515/tnsci-2017-0014 |
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author | Antony, Joseph Mathew Weaver, Ian Rueffer, Matthew Guthrie, Najla Evans, Malkanthi |
author_facet | Antony, Joseph Mathew Weaver, Ian Rueffer, Matthew Guthrie, Najla Evans, Malkanthi |
author_sort | Antony, Joseph Mathew |
collection | PubMed |
description | Cognition is comprised of the faculties: perception, creativity, intuition, and ratiocination. Optimal levels of cognition are needed for independent functioning and balanced living. With an aging population that continues to grow, dietary supplements that tilt the balance towards maintenance of cognition are being marketed for vulnerable populations facing these challenges. Randomized clinical trials provide the causal inference necessary to define the efficacy of emerging nutraceuticals. Cognition testing, in particular, requires a battery of tests that encompass all brain regions involved in cognition so as to provide endpoints necessary for product validation. The lack of well controlled studies for comparison analyses, limited sample sizes, ambiguous dosages, and poor cognitive measures result in data that cannot be compared across studies to determine the efficacy of supplements claiming to enhance cognition. Clinical trials for the nutraceutical industry should consider the multifaceted nature of supplements, where clinical endpoints must be comprehensive while remaining feasible. Combining endpoints of cognition with physiological biomarkers of immunity and metabolism to arrive at a global index for cognitive health may be necessary for claim substantiation in order to fully justify and scientifically validate improvements in cognitive health. The issues and needs of a global index will be discussed here. |
format | Online Article Text |
id | pubmed-5597950 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | De Gruyter Open |
record_format | MEDLINE/PubMed |
spelling | pubmed-55979502017-09-18 The Essentials of a Global Index for Cognitive Function Antony, Joseph Mathew Weaver, Ian Rueffer, Matthew Guthrie, Najla Evans, Malkanthi Transl Neurosci Regular Articles Cognition is comprised of the faculties: perception, creativity, intuition, and ratiocination. Optimal levels of cognition are needed for independent functioning and balanced living. With an aging population that continues to grow, dietary supplements that tilt the balance towards maintenance of cognition are being marketed for vulnerable populations facing these challenges. Randomized clinical trials provide the causal inference necessary to define the efficacy of emerging nutraceuticals. Cognition testing, in particular, requires a battery of tests that encompass all brain regions involved in cognition so as to provide endpoints necessary for product validation. The lack of well controlled studies for comparison analyses, limited sample sizes, ambiguous dosages, and poor cognitive measures result in data that cannot be compared across studies to determine the efficacy of supplements claiming to enhance cognition. Clinical trials for the nutraceutical industry should consider the multifaceted nature of supplements, where clinical endpoints must be comprehensive while remaining feasible. Combining endpoints of cognition with physiological biomarkers of immunity and metabolism to arrive at a global index for cognitive health may be necessary for claim substantiation in order to fully justify and scientifically validate improvements in cognitive health. The issues and needs of a global index will be discussed here. De Gruyter Open 2017-09-12 /pmc/articles/PMC5597950/ /pubmed/28924492 http://dx.doi.org/10.1515/tnsci-2017-0014 Text en © 2017 Joseph Mathew Antony et al. http://creativecommons.org/licenses/by-nc-nd/3.0 This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License. |
spellingShingle | Regular Articles Antony, Joseph Mathew Weaver, Ian Rueffer, Matthew Guthrie, Najla Evans, Malkanthi The Essentials of a Global Index for Cognitive Function |
title | The Essentials of a Global Index for Cognitive Function |
title_full | The Essentials of a Global Index for Cognitive Function |
title_fullStr | The Essentials of a Global Index for Cognitive Function |
title_full_unstemmed | The Essentials of a Global Index for Cognitive Function |
title_short | The Essentials of a Global Index for Cognitive Function |
title_sort | essentials of a global index for cognitive function |
topic | Regular Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5597950/ https://www.ncbi.nlm.nih.gov/pubmed/28924492 http://dx.doi.org/10.1515/tnsci-2017-0014 |
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