Natural genetic variation of the cardiac transcriptome in non-diseased donors and patients with dilated cardiomyopathy

BACKGROUND: Genetic variation is an important determinant of RNA transcription and splicing, which in turn contributes to variation in human traits, including cardiovascular diseases. RESULTS: Here we report the first in-depth survey of heart transcriptome variation using RNA-sequencing in 97 patien...

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Detalles Bibliográficos
Autores principales: Heinig, Matthias, Adriaens, Michiel E., Schafer, Sebastian, van Deutekom, Hanneke W. M., Lodder, Elisabeth M., Ware, James S., Schneider, Valentin, Felkin, Leanne E., Creemers, Esther E., Meder, Benjamin, Katus, Hugo A., Rühle, Frank, Stoll, Monika, Cambien, François, Villard, Eric, Charron, Philippe, Varro, Andras, Bishopric, Nanette H., George, Alfred L., dos Remedios, Cristobal, Moreno-Moral, Aida, Pesce, Francesco, Bauerfeind, Anja, Rüschendorf, Franz, Rintisch, Carola, Petretto, Enrico, Barton, Paul J., Cook, Stuart A., Pinto, Yigal M., Bezzina, Connie R., Hubner, Norbert
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5598015/
https://www.ncbi.nlm.nih.gov/pubmed/28903782
http://dx.doi.org/10.1186/s13059-017-1286-z

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