Fluoxetine-enhanced autophagy ameliorates early brain injury via inhibition of NLRP3 inflammasome activation following subrachnoid hemorrhage in rats

BACKGROUND: The NLRP3 inflammasome is a multiprotein complex that regulates the innate immune inflammatory response by activating caspase-1 and subsequent IL-1β and IL-18. Fluoxetine has been shown to have the anti-inflammatory properties in many disease models. However, the effects and mechanisms o...

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Detalles Bibliográficos
Autores principales: Li, Jian-ru, Xu, Hang-zhe, Nie, Sheng, Peng, Yu-cong, Fan, Lin-Feng, Wang, Zhi-jiang, Wu, Cheng, Yan, Feng, Chen, Jing-yin, Gu, Chi, Wang, Chun, Chen, Jing-sen, Wang, Lin, Chen, Gao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5598033/
https://www.ncbi.nlm.nih.gov/pubmed/28903766
http://dx.doi.org/10.1186/s12974-017-0959-6

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