Liquid dynamic medicine and N-of-1 clinical trials: a change of perspective in oncology research

The increasing use of genomics to define the pattern of actionable mutations and to test and validate new therapies for individual cancer patients, and the growing application of liquid biopsy to dynamically track tumor evolution and to adapt molecularly targeted therapy according to the emergence o...

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Autores principales: Silvestris, Nicola, Ciliberto, Gennaro, De Paoli, Paolo, Apolone, Giovanni, Lavitrano, Maria Luisa, Pierotti, Marco A., Stanta, Giorgio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5598055/
https://www.ncbi.nlm.nih.gov/pubmed/28903768
http://dx.doi.org/10.1186/s13046-017-0598-x
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author Silvestris, Nicola
Ciliberto, Gennaro
De Paoli, Paolo
Apolone, Giovanni
Lavitrano, Maria Luisa
Pierotti, Marco A.
Stanta, Giorgio
author_facet Silvestris, Nicola
Ciliberto, Gennaro
De Paoli, Paolo
Apolone, Giovanni
Lavitrano, Maria Luisa
Pierotti, Marco A.
Stanta, Giorgio
author_sort Silvestris, Nicola
collection PubMed
description The increasing use of genomics to define the pattern of actionable mutations and to test and validate new therapies for individual cancer patients, and the growing application of liquid biopsy to dynamically track tumor evolution and to adapt molecularly targeted therapy according to the emergence of tumor clonal variants is shaping modern medical oncology., In order to better describe this new therapeutic paradigm we propose the term “Liquid dynamic medicine” in the place of “Personalized or Precision medicine”. Clinical validation of the “Liquid dynamic medicine” approach is best captured by N-of-1 trials where each patient acts as tester and control of truly personalized therapies.
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spelling pubmed-55980552017-09-18 Liquid dynamic medicine and N-of-1 clinical trials: a change of perspective in oncology research Silvestris, Nicola Ciliberto, Gennaro De Paoli, Paolo Apolone, Giovanni Lavitrano, Maria Luisa Pierotti, Marco A. Stanta, Giorgio J Exp Clin Cancer Res Review The increasing use of genomics to define the pattern of actionable mutations and to test and validate new therapies for individual cancer patients, and the growing application of liquid biopsy to dynamically track tumor evolution and to adapt molecularly targeted therapy according to the emergence of tumor clonal variants is shaping modern medical oncology., In order to better describe this new therapeutic paradigm we propose the term “Liquid dynamic medicine” in the place of “Personalized or Precision medicine”. Clinical validation of the “Liquid dynamic medicine” approach is best captured by N-of-1 trials where each patient acts as tester and control of truly personalized therapies. BioMed Central 2017-09-13 /pmc/articles/PMC5598055/ /pubmed/28903768 http://dx.doi.org/10.1186/s13046-017-0598-x Text en © The Author(s). 2017 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Review
Silvestris, Nicola
Ciliberto, Gennaro
De Paoli, Paolo
Apolone, Giovanni
Lavitrano, Maria Luisa
Pierotti, Marco A.
Stanta, Giorgio
Liquid dynamic medicine and N-of-1 clinical trials: a change of perspective in oncology research
title Liquid dynamic medicine and N-of-1 clinical trials: a change of perspective in oncology research
title_full Liquid dynamic medicine and N-of-1 clinical trials: a change of perspective in oncology research
title_fullStr Liquid dynamic medicine and N-of-1 clinical trials: a change of perspective in oncology research
title_full_unstemmed Liquid dynamic medicine and N-of-1 clinical trials: a change of perspective in oncology research
title_short Liquid dynamic medicine and N-of-1 clinical trials: a change of perspective in oncology research
title_sort liquid dynamic medicine and n-of-1 clinical trials: a change of perspective in oncology research
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5598055/
https://www.ncbi.nlm.nih.gov/pubmed/28903768
http://dx.doi.org/10.1186/s13046-017-0598-x
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