Stat-6 signaling pathway and not Interleukin-1 mediates multi-walled carbon nanotube-induced lung fibrosis in mice: insights from an adverse outcome pathway framework

BACKGROUND: The accumulation of MWCNTs in the lung environment leads to inflammation and the development of disease similar to pulmonary fibrosis in rodents. Adverse Outcome Pathways (AOPs) are a framework for defining and organizing the key events that comprise the biological changes leading to und...

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Detalles Bibliográficos
Autores principales: Nikota, Jake, Banville, Allyson, Goodwin, Laura Rose, Wu, Dongmei, Williams, Andrew, Yauk, Carole Lynn, Wallin, Håkan, Vogel, Ulla, Halappanavar, Sabina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5598059/
https://www.ncbi.nlm.nih.gov/pubmed/28903780
http://dx.doi.org/10.1186/s12989-017-0218-0

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