Cargando…

FOXP3 Is a HCC suppressor gene and Acts through regulating the TGF-β/Smad2/3 signaling pathway

BACKGROUND: FOXP3 has been discovered to be expressed in tumor cells and participate in the regulation of tumor behavior. Herein, we investigated the clinical relevance and biological significance of FOXP3 expression in human hepatocellular carcinoma (HCC). METHODS: Expression profile of FOXP3 was a...

Descripción completa

Detalles Bibliográficos
Autores principales:	Shi, Jie-Yi, Ma, Li-Jie, Zhang, Ji-Wei, Duan, Meng, Ding, Zhen-Bin, Yang, Liu-Xiao, Cao, Ya, Zhou, Jian, Fan, Jia, Zhang, Xiaoming, Zhao, Ying-Jun, Wang, Xiao-Ying, Gao, Qiang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2017
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5598072/ https://www.ncbi.nlm.nih.gov/pubmed/28903735 http://dx.doi.org/10.1186/s12885-017-3633-6

Ejemplares similares

TGF-β/Smad Signaling Pathway in Tubulointerstitial Fibrosis
por: Yu, Xiao-Yong, et al.
Publicado: (2022)

TGF-β1 suppresses the T-cell response in teleost fish by initiating Smad3- and Foxp3-mediated transcriptional networks
por: Zhang, Qian, et al.
Publicado: (2022)

MIR22HG acts as a tumor suppressor via TGFβ/SMAD signaling and facilitates immunotherapy in colorectal cancer
por: Xu, Juan, et al.
Publicado: (2020)

Exosomes derived from HCC cells with different invasion characteristics mediated EMT through TGF-β/Smad signaling pathway
por: Qu, Zhen, et al.
Publicado: (2019)

Correction: MIR22HG acts as a tumor suppressor via TGFβ/SMAD signaling and facilitates immunotherapy in colorectal cancer
por: Xu, Juan, et al.
Publicado: (2023)

Golgi scaffold protein PAQR3 as a candidate suppressor of gastric cardia adenocarcinoma via regulating TGF‐β/Smad pathway
por: Wu, Ying‐Li, et al.
Publicado: (2022)

Non-degradative ubiquitination in Smad-dependent TGF-β signaling
por: Tang, Liu-Ya, et al.
Publicado: (2011)

Elevated FBXL18 promotes RPS15A ubiquitination and SMAD3 activation to drive HCC
por: Yu, Hong-Qiang, et al.
Publicado: (2023)

TGF-β1 maintains suppressor function and Foxp3 expression in CD4(+)CD25(+) regulatory T cells
por: Marie, Julien C., et al.
Publicado: (2005)

Aspirin inhibits endometrial fibrosis by suppressing the TGF-β1-Smad2/Smad3 pathway in intrauterine adhesions
por: Zhang, Zihui, et al.
Publicado: (2020)

MiR‐133a acts as a tumor suppressor in lung cancer progression by regulating the LASP1 and TGF‐β/Smad3 signaling pathway
por: Shen, Yuyao, et al.
Publicado: (2020)

TGFβ/Smad3 signal pathway is not required for epidermal langerhans cell development
por: Xu, Ying-Ping, et al.
Publicado: (2012)

miR-494 induces EndMT and promotes the development of HCC (Hepatocellular Carcinoma) by targeting SIRT3/TGF-β/SMAD signaling pathway
por: Zhang, Jinqian, et al.
Publicado: (2019)

Bcl-3 regulates TGFβ signaling by stabilizing Smad3 during breast cancer pulmonary metastasis
por: Chen, Xi, et al.
Publicado: (2016)

Protection from β-cell apoptosis by inhibition of TGF-β/Smad3 signaling
por: Lee, Ji-Hyeon, et al.
Publicado: (2020)

Special role of Foxp3 for the specifically altered microRNAs in Regulatory T cells of HCC patients
por: Chen, Long, et al.
Publicado: (2014)

The expression of TGF-β1, Smad3, phospho-Smad3 and Smad7 is correlated with the development and invasion of nonfunctioning pituitary adenomas
por: Zhenye, Li, et al.
Publicado: (2014)

Alterations in TGF-β signaling leads to high HMGA2 levels potentially through modulation of PJA1/SMAD3 in HCC cells
por: Ohshiro, Kazufumi, et al.
Publicado: (2020)

Interleukin 4 inhibits TGF-β-induced-Foxp3(+)T cells and generates, in combination with TGF-β, Foxp3(−) effector T cells that produce interleukins 9 and 10
por: Dardalhon, Valérie, et al.
Publicado: (2008)

Pregnancy‐specific glycoprotein 9 acts as both a transcriptional target and a regulator of the canonical TGF‐β/Smad signaling to drive breast cancer progression
por: Liu, Ying‐Ying, et al.
Publicado: (2020)

Knockdown of Secernin 1 inhibit cell invasion and migration by activating the TGF-β/Smad3 pathway in oral squamous cell carcinomas
por: Xiao, Li, et al.
Publicado: (2023)

Downregulation of FOXP2 promotes breast cancer migration and invasion through TGFβ/SMAD signaling pathway
por: Chen, Meng-Ting, et al.
Publicado: (2018)

TGF-β/Smad3 signalling regulates the transition of bone marrow-derived macrophages into myofibroblasts during tissue fibrosis
por: Wang, Shuang, et al.
Publicado: (2015)

SMAD2/3 mediate oncogenic effects of TGF-β in the absence of SMAD4
por: Bertrand-Chapel, Adrien, et al.
Publicado: (2022)

Chinese 1 strain of Toxoplasma gondii excreted–secreted antigens negatively modulate Foxp3 via inhibition of the TGFßRII/Smad2/Smad3/Smad4 pathway
por: Chen, Jinling, et al.
Publicado: (2017)

Molecular Mechanisms Regulating TGF-β-Induced Foxp3 Expression
por: Xu, Lili, et al.
Publicado: (2010)

SP1/TGF-β1/SMAD2 pathway is involved in angiogenesis during osteogenesis
por: Ding, Ao, et al.
Publicado: (2020)

Smad2 and Smad3 have differential sensitivity in relaying TGFβ signaling and inversely regulate early lineage specification
por: Liu, Ling, et al.
Publicado: (2016)

Analysis of Suppressor and Non-Suppressor FOXP3+ T Cells in HIV-1-Infected Patients
por: Arruvito, Lourdes, et al.
Publicado: (2012)

TrkB-Induced Inhibition of R-SMAD/SMAD4 Activation is Essential for TGF-β-Mediated Tumor Suppressor Activity
por: Kim, Min Soo, et al.
Publicado: (2020)

Naringenin prevents experimental liver fibrosis by blocking TGFβ-Smad3 and JNK-Smad3 pathways
por: Hernández-Aquino, Erika, et al.
Publicado: (2017)

TGF-β/Smad signaling in renal fibrosis
por: Meng, Xiao-Ming, et al.
Publicado: (2015)

Endoglin aggravates peritoneal fibrosis by regulating the activation of TGF-β/ALK/Smads signaling
por: Huang, Qian, et al.
Publicado: (2022)

Ahnak functions as a tumor suppressor via modulation of TGFβ/Smad signaling pathway
por: Lee, I H, et al.
Publicado: (2014)

Smad4-mediated TGF-β signaling in tumorigenesis
por: Yang, Guan, et al.
Publicado: (2010)

Structural basis for distinct roles of SMAD2 and SMAD3 in FOXH1 pioneer-directed TGF-β signaling
por: Aragón, Eric, et al.
Publicado: (2019)

STAT3 selectively interacts with Smad3 to antagonize TGF-β signaling
por: Wang, Gaohang, et al.
Publicado: (2015)

TGF‐β1 promotes gap junctions formation in chondrocytes via Smad3/Smad4 signalling
por: Wang, Qingxuan, et al.
Publicado: (2018)

ENMD-1068 inhibits liver fibrosis through attenuation of TGF-β1/Smad2/3 signaling in mice
por: Sun, Quan, et al.
Publicado: (2017)

KRT7 promotes epithelial-mesenchymal transition in ovarian cancer via the TGF-β/Smad2/3 signaling pathway
por: An, Qiang, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_tcj6u6nro565d3gg0fklf428mf