Cargando…
Oral repeated-dose systemic and reproductive toxicity of 6:2 fluorotelomer alcohol in mice
6:2 fluorotelomer alcohol (6:2 FTOH) was evaluated for potential systemic repeated-dose and reproductive toxicity in mice. 6:2 FTOH was administered by oral gavage to CD-1 mice as a suspension in 0.5% aqueous methylcellulose with 0.1% Tween-80 at dosages of 1, 5, 25, or 100 mg/kg/day. The no-observe...
Autores principales: | , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2014
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5598097/ https://www.ncbi.nlm.nih.gov/pubmed/28962345 http://dx.doi.org/10.1016/j.toxrep.2014.12.002 |
_version_ | 1783263832883331072 |
---|---|
author | Mukerji, Pushkor Rae, Jessica Caverly Buck, Robert C. O’Connor, John C. |
author_facet | Mukerji, Pushkor Rae, Jessica Caverly Buck, Robert C. O’Connor, John C. |
author_sort | Mukerji, Pushkor |
collection | PubMed |
description | 6:2 fluorotelomer alcohol (6:2 FTOH) was evaluated for potential systemic repeated-dose and reproductive toxicity in mice. 6:2 FTOH was administered by oral gavage to CD-1 mice as a suspension in 0.5% aqueous methylcellulose with 0.1% Tween-80 at dosages of 1, 5, 25, or 100 mg/kg/day. The no-observed-adverse-effect level (NOAEL) for systemic toxicity was 25 mg/kg/day (males) and 5 mg/kg/day (females), based on effects at higher doses on mortality, clinical observations, body weight, nutritional parameters, hematology (red and white blood cell), clinical chemistry (liver-related), liver weights, and histopathology (liver, teeth, reproductive tract, and mammary gland). However, 6:2 FTOH was not a selective reproductive toxicant. The NOAEL for reproductive toxicity was >100 mg/kg/day; no effects on reproductive outcome were observed at any dosage. The NOAEL for viability and growth of the offspring was 25 mg/kg/day, based on clinical signs of delayed maturation in pups, and reductions in pup survival and pup body weight during lactation at 100 mg/kg/day. While the severity of the effects was generally greater in mice than previously reported in CD rats, the overall NOAELs were identical in both species, 5 mg/kg/day for systemic toxicity and 25 mg/kg/day for offspring viability/growth. 6:2 FTOH was not a selective reproductive toxicant in either species; no effects on reproductive outcome occurred at any dose level, and any effects observed in offspring occurred at dose levels that induced mortality and severe toxicity in maternal animals. |
format | Online Article Text |
id | pubmed-5598097 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-55980972017-09-28 Oral repeated-dose systemic and reproductive toxicity of 6:2 fluorotelomer alcohol in mice Mukerji, Pushkor Rae, Jessica Caverly Buck, Robert C. O’Connor, John C. Toxicol Rep Article 6:2 fluorotelomer alcohol (6:2 FTOH) was evaluated for potential systemic repeated-dose and reproductive toxicity in mice. 6:2 FTOH was administered by oral gavage to CD-1 mice as a suspension in 0.5% aqueous methylcellulose with 0.1% Tween-80 at dosages of 1, 5, 25, or 100 mg/kg/day. The no-observed-adverse-effect level (NOAEL) for systemic toxicity was 25 mg/kg/day (males) and 5 mg/kg/day (females), based on effects at higher doses on mortality, clinical observations, body weight, nutritional parameters, hematology (red and white blood cell), clinical chemistry (liver-related), liver weights, and histopathology (liver, teeth, reproductive tract, and mammary gland). However, 6:2 FTOH was not a selective reproductive toxicant. The NOAEL for reproductive toxicity was >100 mg/kg/day; no effects on reproductive outcome were observed at any dosage. The NOAEL for viability and growth of the offspring was 25 mg/kg/day, based on clinical signs of delayed maturation in pups, and reductions in pup survival and pup body weight during lactation at 100 mg/kg/day. While the severity of the effects was generally greater in mice than previously reported in CD rats, the overall NOAELs were identical in both species, 5 mg/kg/day for systemic toxicity and 25 mg/kg/day for offspring viability/growth. 6:2 FTOH was not a selective reproductive toxicant in either species; no effects on reproductive outcome occurred at any dose level, and any effects observed in offspring occurred at dose levels that induced mortality and severe toxicity in maternal animals. Elsevier 2014-12-15 /pmc/articles/PMC5598097/ /pubmed/28962345 http://dx.doi.org/10.1016/j.toxrep.2014.12.002 Text en © 2014 The Authors http://creativecommons.org/licenses/by-nc-nd/3.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/3.0/). |
spellingShingle | Article Mukerji, Pushkor Rae, Jessica Caverly Buck, Robert C. O’Connor, John C. Oral repeated-dose systemic and reproductive toxicity of 6:2 fluorotelomer alcohol in mice |
title | Oral repeated-dose systemic and reproductive toxicity of 6:2 fluorotelomer alcohol in mice |
title_full | Oral repeated-dose systemic and reproductive toxicity of 6:2 fluorotelomer alcohol in mice |
title_fullStr | Oral repeated-dose systemic and reproductive toxicity of 6:2 fluorotelomer alcohol in mice |
title_full_unstemmed | Oral repeated-dose systemic and reproductive toxicity of 6:2 fluorotelomer alcohol in mice |
title_short | Oral repeated-dose systemic and reproductive toxicity of 6:2 fluorotelomer alcohol in mice |
title_sort | oral repeated-dose systemic and reproductive toxicity of 6:2 fluorotelomer alcohol in mice |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5598097/ https://www.ncbi.nlm.nih.gov/pubmed/28962345 http://dx.doi.org/10.1016/j.toxrep.2014.12.002 |
work_keys_str_mv | AT mukerjipushkor oralrepeateddosesystemicandreproductivetoxicityof62fluorotelomeralcoholinmice AT raejessicacaverly oralrepeateddosesystemicandreproductivetoxicityof62fluorotelomeralcoholinmice AT buckrobertc oralrepeateddosesystemicandreproductivetoxicityof62fluorotelomeralcoholinmice AT oconnorjohnc oralrepeateddosesystemicandreproductivetoxicityof62fluorotelomeralcoholinmice |