Cargando…
The impact of cardiac resynchronization therapy on routine laboratory parameters
BACKGROUND: Cardiac resynchronization therapy (CRT) in chronic heart failure has been shown to improve mortality and morbidity. However, comprehensive data are not available as concerns how circulating biomarkers reflecting different organ functions, such as serum uric acid, blood urea nitrogen (BUN...
Autores principales: | , , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Akadémiai Kiadó
2017
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5598115/ https://www.ncbi.nlm.nih.gov/pubmed/28932489 http://dx.doi.org/10.1556/1646.9.2017.1.01 |
_version_ | 1783263836919300096 |
---|---|
author | Boros, András Mihály Perge, Péter Nagy, Klaudia Vivien Apor, Astrid Bagyura, Zsolt Zima, Endre Molnár, Levente Tahin, Tamás Becker, Dávid Gellér, László Merkely, Béla Széplaki, Gábor |
author_facet | Boros, András Mihály Perge, Péter Nagy, Klaudia Vivien Apor, Astrid Bagyura, Zsolt Zima, Endre Molnár, Levente Tahin, Tamás Becker, Dávid Gellér, László Merkely, Béla Széplaki, Gábor |
author_sort | Boros, András Mihály |
collection | PubMed |
description | BACKGROUND: Cardiac resynchronization therapy (CRT) in chronic heart failure has been shown to improve mortality and morbidity. However, comprehensive data are not available as concerns how circulating biomarkers reflecting different organ functions, such as serum uric acid, blood urea nitrogen (BUN), albumin, cholesterol, or various liver enzymes, change over time as a consequence of CRT. The aim of this prospective study was to overview these possible changes. METHODS: A total of 20 routine laboratory parameters were measured in 122 control subjects and in 129 patients with chronic heart failure before CRT, 6 months, and 2 years later. RESULTS: The levels of serum uric acid [before: 432 (331–516) mmol/L, 6-month: 372 (304–452) mmol/L, 2-year: 340 (290–433) mmol/L; p < 0.001] and BUN [8.3 (6.4–11.5) mmol/L, 8.0 (6.3–11.1) mmol/L, 6.8 (5.0–9.7) mmol/L; p < 0.001) reduced statistically significant. Total bilirubin underwent reduction [16 (11–23) μmol/L, 11 (7–14) μmol/L, 8 (7–13) μmol/L; p < 0.001], while albumin increased [45 (43–48) g/L, 46 (44–48) g/L, 46 (43–48) g/L; p = 0.04]. Cholesterol concentrations elevated [4.3 (3.6–5.0) mmol/L, 4.5 (3.8–5.1) mmol/L, 4.6 (3.8–5.4) mmol/L; p < 0.001] and glucose decreased [6.2 (5.6–7.2) mmol/L, 5.9 (5.1–6.7) mmol/L, 5.7 (5.1–6.8) mmol/L; p < 0.001]. CONCLUSIONS: CRT influences the levels of routinely used biomarkers suggesting improvements in renal function, liver capacity, and metabolic changes. These changes could mirror the multiorgan improvement after CRT. |
format | Online Article Text |
id | pubmed-5598115 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Akadémiai Kiadó |
record_format | MEDLINE/PubMed |
spelling | pubmed-55981152017-09-20 The impact of cardiac resynchronization therapy on routine laboratory parameters Boros, András Mihály Perge, Péter Nagy, Klaudia Vivien Apor, Astrid Bagyura, Zsolt Zima, Endre Molnár, Levente Tahin, Tamás Becker, Dávid Gellér, László Merkely, Béla Széplaki, Gábor Interv Med Appl Sci Original Paper BACKGROUND: Cardiac resynchronization therapy (CRT) in chronic heart failure has been shown to improve mortality and morbidity. However, comprehensive data are not available as concerns how circulating biomarkers reflecting different organ functions, such as serum uric acid, blood urea nitrogen (BUN), albumin, cholesterol, or various liver enzymes, change over time as a consequence of CRT. The aim of this prospective study was to overview these possible changes. METHODS: A total of 20 routine laboratory parameters were measured in 122 control subjects and in 129 patients with chronic heart failure before CRT, 6 months, and 2 years later. RESULTS: The levels of serum uric acid [before: 432 (331–516) mmol/L, 6-month: 372 (304–452) mmol/L, 2-year: 340 (290–433) mmol/L; p < 0.001] and BUN [8.3 (6.4–11.5) mmol/L, 8.0 (6.3–11.1) mmol/L, 6.8 (5.0–9.7) mmol/L; p < 0.001) reduced statistically significant. Total bilirubin underwent reduction [16 (11–23) μmol/L, 11 (7–14) μmol/L, 8 (7–13) μmol/L; p < 0.001], while albumin increased [45 (43–48) g/L, 46 (44–48) g/L, 46 (43–48) g/L; p = 0.04]. Cholesterol concentrations elevated [4.3 (3.6–5.0) mmol/L, 4.5 (3.8–5.1) mmol/L, 4.6 (3.8–5.4) mmol/L; p < 0.001] and glucose decreased [6.2 (5.6–7.2) mmol/L, 5.9 (5.1–6.7) mmol/L, 5.7 (5.1–6.8) mmol/L; p < 0.001]. CONCLUSIONS: CRT influences the levels of routinely used biomarkers suggesting improvements in renal function, liver capacity, and metabolic changes. These changes could mirror the multiorgan improvement after CRT. Akadémiai Kiadó 2017-03-25 2017-03 /pmc/articles/PMC5598115/ /pubmed/28932489 http://dx.doi.org/10.1556/1646.9.2017.1.01 Text en © 2017 The Author(s) http://creativecommons.org/licenses/by-nc/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium for non-commercial purposes, provided the original author and source are credited. |
spellingShingle | Original Paper Boros, András Mihály Perge, Péter Nagy, Klaudia Vivien Apor, Astrid Bagyura, Zsolt Zima, Endre Molnár, Levente Tahin, Tamás Becker, Dávid Gellér, László Merkely, Béla Széplaki, Gábor The impact of cardiac resynchronization therapy on routine laboratory parameters |
title | The impact of cardiac resynchronization therapy on routine laboratory parameters |
title_full | The impact of cardiac resynchronization therapy on routine laboratory parameters |
title_fullStr | The impact of cardiac resynchronization therapy on routine laboratory parameters |
title_full_unstemmed | The impact of cardiac resynchronization therapy on routine laboratory parameters |
title_short | The impact of cardiac resynchronization therapy on routine laboratory parameters |
title_sort | impact of cardiac resynchronization therapy on routine laboratory parameters |
topic | Original Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5598115/ https://www.ncbi.nlm.nih.gov/pubmed/28932489 http://dx.doi.org/10.1556/1646.9.2017.1.01 |
work_keys_str_mv | AT borosandrasmihaly theimpactofcardiacresynchronizationtherapyonroutinelaboratoryparameters AT pergepeter theimpactofcardiacresynchronizationtherapyonroutinelaboratoryparameters AT nagyklaudiavivien theimpactofcardiacresynchronizationtherapyonroutinelaboratoryparameters AT aporastrid theimpactofcardiacresynchronizationtherapyonroutinelaboratoryparameters AT bagyurazsolt theimpactofcardiacresynchronizationtherapyonroutinelaboratoryparameters AT zimaendre theimpactofcardiacresynchronizationtherapyonroutinelaboratoryparameters AT molnarlevente theimpactofcardiacresynchronizationtherapyonroutinelaboratoryparameters AT tahintamas theimpactofcardiacresynchronizationtherapyonroutinelaboratoryparameters AT beckerdavid theimpactofcardiacresynchronizationtherapyonroutinelaboratoryparameters AT gellerlaszlo theimpactofcardiacresynchronizationtherapyonroutinelaboratoryparameters AT merkelybela theimpactofcardiacresynchronizationtherapyonroutinelaboratoryparameters AT szeplakigabor theimpactofcardiacresynchronizationtherapyonroutinelaboratoryparameters AT borosandrasmihaly impactofcardiacresynchronizationtherapyonroutinelaboratoryparameters AT pergepeter impactofcardiacresynchronizationtherapyonroutinelaboratoryparameters AT nagyklaudiavivien impactofcardiacresynchronizationtherapyonroutinelaboratoryparameters AT aporastrid impactofcardiacresynchronizationtherapyonroutinelaboratoryparameters AT bagyurazsolt impactofcardiacresynchronizationtherapyonroutinelaboratoryparameters AT zimaendre impactofcardiacresynchronizationtherapyonroutinelaboratoryparameters AT molnarlevente impactofcardiacresynchronizationtherapyonroutinelaboratoryparameters AT tahintamas impactofcardiacresynchronizationtherapyonroutinelaboratoryparameters AT beckerdavid impactofcardiacresynchronizationtherapyonroutinelaboratoryparameters AT gellerlaszlo impactofcardiacresynchronizationtherapyonroutinelaboratoryparameters AT merkelybela impactofcardiacresynchronizationtherapyonroutinelaboratoryparameters AT szeplakigabor impactofcardiacresynchronizationtherapyonroutinelaboratoryparameters |