Potential toxicity of quercetin: The repression of mitochondrial copy number via decreased POLG expression and excessive TFAM expression in irradiated murine bone marrow

The cytotoxicity of quercetin is not well understood. Using an ICR murine model, we unexpectedly found that mice exposed to 7 Gy total body irradiation (TBI) exhibited general in vivo toxicity after receiving quercetin (100 mg/kg PO), whereas this result was not observed in mice that received TBI on...

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Detalles Bibliográficos
Autores principales: Chen, Ruiqing, Lin, Jingan, Hong, Jingshen, Han, Deping, Zhang, Addison D., Lan, Ruilong, Fu, Lengxi, Wu, Zhaoyang, Lin, Jianhua, Zhang, Weijian, Wang, Zeng, Chen, Wei, Chen, Chun, Zhang, Hengshan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5598249/
https://www.ncbi.nlm.nih.gov/pubmed/28962259
http://dx.doi.org/10.1016/j.toxrep.2014.07.014

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