Concentration- and time-dependent genotoxicity profiles of isoprene monoepoxides and diepoxide, and the cross-linking potential of isoprene diepoxide in cells

Isoprene, a possible carcinogen, is a petrochemical and a natural product being primarily produced by plants. It is biotransformed to 2-ethenyl-2-methyloxirane (IP-1,2-O) and 2-(1-methylethenyl)oxirane (IP-3,4-O), both of which can be further metabolized to 2-methyl-2,2′-bioxirane (MBO). MBO is muta...

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Detalles Bibliográficos
Autores principales: Li, Yan, Pelah, Avishay, An, Jing, Yu, Ying-Xin, Zhang, Xin-Yu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5598284/
https://www.ncbi.nlm.nih.gov/pubmed/28962224
http://dx.doi.org/10.1016/j.toxrep.2014.03.002

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5598284/
https://www.ncbi.nlm.nih.gov/pubmed/28962224
http://dx.doi.org/10.1016/j.toxrep.2014.03.002

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