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Safety assessment of the microalgae Nannochloropsis oculata

Nannochloropsis oculata is a marine-water microalgae that is considered to be a good source of omega-3 fatty acids, specifically eicosapentaenoic acid (EPA), utilized in the production of an omega-3 oil for use as a dietary supplement. This study investigates the safety of N. oculata in male and fem...

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Detalles Bibliográficos
Autores principales: Kagan, Michael L., Matulka, Ray A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5598295/
https://www.ncbi.nlm.nih.gov/pubmed/28962397
http://dx.doi.org/10.1016/j.toxrep.2015.03.008
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author Kagan, Michael L.
Matulka, Ray A.
author_facet Kagan, Michael L.
Matulka, Ray A.
author_sort Kagan, Michael L.
collection PubMed
description Nannochloropsis oculata is a marine-water microalgae that is considered to be a good source of omega-3 fatty acids, specifically eicosapentaenoic acid (EPA), utilized in the production of an omega-3 oil for use as a dietary supplement. This study investigates the safety of N. oculata in male and female Sprague-Dawley rats administered a 0 or 10 mL/kg bw/rat N. oculata (10E8 viable cells/mL) suspension by oral gavage once daily for 14 consecutive days. No mortalities occurred and no signs of toxicity were observed during the study. No treatment-related effects were seen for body weight, food consumption, urinalysis, clinical chemistry, hematology, gross pathology, organ weights, or histopathology. Although statistically significant effects were noted for some endpoints, none were considered to be of toxicological significance. The N. oculata suspension was concluded to have no toxicity in rats, confirming that the algal strain used in the production of omega-3 oil is not pathogenic when administered orally to rats.
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spelling pubmed-55982952017-09-28 Safety assessment of the microalgae Nannochloropsis oculata Kagan, Michael L. Matulka, Ray A. Toxicol Rep Article Nannochloropsis oculata is a marine-water microalgae that is considered to be a good source of omega-3 fatty acids, specifically eicosapentaenoic acid (EPA), utilized in the production of an omega-3 oil for use as a dietary supplement. This study investigates the safety of N. oculata in male and female Sprague-Dawley rats administered a 0 or 10 mL/kg bw/rat N. oculata (10E8 viable cells/mL) suspension by oral gavage once daily for 14 consecutive days. No mortalities occurred and no signs of toxicity were observed during the study. No treatment-related effects were seen for body weight, food consumption, urinalysis, clinical chemistry, hematology, gross pathology, organ weights, or histopathology. Although statistically significant effects were noted for some endpoints, none were considered to be of toxicological significance. The N. oculata suspension was concluded to have no toxicity in rats, confirming that the algal strain used in the production of omega-3 oil is not pathogenic when administered orally to rats. Elsevier 2015-04-08 /pmc/articles/PMC5598295/ /pubmed/28962397 http://dx.doi.org/10.1016/j.toxrep.2015.03.008 Text en © 2015 The Authors http://creativecommons.org/licenses/by/4.0/ This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Kagan, Michael L.
Matulka, Ray A.
Safety assessment of the microalgae Nannochloropsis oculata
title Safety assessment of the microalgae Nannochloropsis oculata
title_full Safety assessment of the microalgae Nannochloropsis oculata
title_fullStr Safety assessment of the microalgae Nannochloropsis oculata
title_full_unstemmed Safety assessment of the microalgae Nannochloropsis oculata
title_short Safety assessment of the microalgae Nannochloropsis oculata
title_sort safety assessment of the microalgae nannochloropsis oculata
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5598295/
https://www.ncbi.nlm.nih.gov/pubmed/28962397
http://dx.doi.org/10.1016/j.toxrep.2015.03.008
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