Cargando…

Green tea extract attenuates CCl4-induced hepatic injury in male hamsters via inhibition of lipid peroxidation and p53-mediated apoptosis

Keeping in mind the beneficial effects of GTE administration on liver damage, the present study was undertaken to evaluate the hepatoprotective effect of green tea extract (GTE) against carbon tetrachloride (CCl4)-induced liver injuries in male hamsters for 8 weeks. Twenty hamsters were equally divi...

Descripción completa

Detalles Bibliográficos
Autores principales: Elgawish, Rania Abdel Rahman, Rahman, Haidy G. Abdel, Abdelrazek, Heba M.A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5598372/
https://www.ncbi.nlm.nih.gov/pubmed/28962456
http://dx.doi.org/10.1016/j.toxrep.2015.08.001
_version_ 1783263891765067776
author Elgawish, Rania Abdel Rahman
Rahman, Haidy G. Abdel
Abdelrazek, Heba M.A.
author_facet Elgawish, Rania Abdel Rahman
Rahman, Haidy G. Abdel
Abdelrazek, Heba M.A.
author_sort Elgawish, Rania Abdel Rahman
collection PubMed
description Keeping in mind the beneficial effects of GTE administration on liver damage, the present study was undertaken to evaluate the hepatoprotective effect of green tea extract (GTE) against carbon tetrachloride (CCl4)-induced liver injuries in male hamsters for 8 weeks. Twenty hamsters were equally divided into 4 groups, the control ones (group I) received only dis. water. Hamsters of group II had free access to 10% of GTE, while hamsters of group III received 1 ml/kg of 50% CCl4 in corn oil via gavage daily. Hamsters of group IV (GTE + CCl4) received a free access to GTE supplementation in combination with 1 ml/kg of 50% CCl4 in corn oil via gavage daily. Lipid profile, hepatic enzyme levels and apoptosis molecular marker (p53) were investigated in hamsters. GTE + CCl4 treated hamsters showed lower levels of hepatic malondialdehyde (MDA) than CCl4 exposed hamsters. Hepatic activity levels of GSH, ALD and cytochrome 450 reductase were declined after CCl4 administration while they were remarkably improved with GTE administration. Serum lipid profiles as T-cholesterol (TC), triglyceride (TG) and low density lipoproteins (LDL) were improved in GTE and CCl4 treated hamsters than CCl4 group. Moreover, hepatic tissue damage and p53 expression induced with CCl4 were improved with the treatment of GTE. These results suggested that GTE possesses hepatoprotective properties against the effect of CCl4.
format Online
Article
Text
id pubmed-5598372
institution National Center for Biotechnology Information
language English
publishDate 2015
publisher Elsevier
record_format MEDLINE/PubMed
spelling pubmed-55983722017-09-28 Green tea extract attenuates CCl4-induced hepatic injury in male hamsters via inhibition of lipid peroxidation and p53-mediated apoptosis Elgawish, Rania Abdel Rahman Rahman, Haidy G. Abdel Abdelrazek, Heba M.A. Toxicol Rep Article Keeping in mind the beneficial effects of GTE administration on liver damage, the present study was undertaken to evaluate the hepatoprotective effect of green tea extract (GTE) against carbon tetrachloride (CCl4)-induced liver injuries in male hamsters for 8 weeks. Twenty hamsters were equally divided into 4 groups, the control ones (group I) received only dis. water. Hamsters of group II had free access to 10% of GTE, while hamsters of group III received 1 ml/kg of 50% CCl4 in corn oil via gavage daily. Hamsters of group IV (GTE + CCl4) received a free access to GTE supplementation in combination with 1 ml/kg of 50% CCl4 in corn oil via gavage daily. Lipid profile, hepatic enzyme levels and apoptosis molecular marker (p53) were investigated in hamsters. GTE + CCl4 treated hamsters showed lower levels of hepatic malondialdehyde (MDA) than CCl4 exposed hamsters. Hepatic activity levels of GSH, ALD and cytochrome 450 reductase were declined after CCl4 administration while they were remarkably improved with GTE administration. Serum lipid profiles as T-cholesterol (TC), triglyceride (TG) and low density lipoproteins (LDL) were improved in GTE and CCl4 treated hamsters than CCl4 group. Moreover, hepatic tissue damage and p53 expression induced with CCl4 were improved with the treatment of GTE. These results suggested that GTE possesses hepatoprotective properties against the effect of CCl4. Elsevier 2015-08-10 /pmc/articles/PMC5598372/ /pubmed/28962456 http://dx.doi.org/10.1016/j.toxrep.2015.08.001 Text en © 2015 The Authors http://creativecommons.org/licenses/by/4.0/ This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Elgawish, Rania Abdel Rahman
Rahman, Haidy G. Abdel
Abdelrazek, Heba M.A.
Green tea extract attenuates CCl4-induced hepatic injury in male hamsters via inhibition of lipid peroxidation and p53-mediated apoptosis
title Green tea extract attenuates CCl4-induced hepatic injury in male hamsters via inhibition of lipid peroxidation and p53-mediated apoptosis
title_full Green tea extract attenuates CCl4-induced hepatic injury in male hamsters via inhibition of lipid peroxidation and p53-mediated apoptosis
title_fullStr Green tea extract attenuates CCl4-induced hepatic injury in male hamsters via inhibition of lipid peroxidation and p53-mediated apoptosis
title_full_unstemmed Green tea extract attenuates CCl4-induced hepatic injury in male hamsters via inhibition of lipid peroxidation and p53-mediated apoptosis
title_short Green tea extract attenuates CCl4-induced hepatic injury in male hamsters via inhibition of lipid peroxidation and p53-mediated apoptosis
title_sort green tea extract attenuates ccl4-induced hepatic injury in male hamsters via inhibition of lipid peroxidation and p53-mediated apoptosis
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5598372/
https://www.ncbi.nlm.nih.gov/pubmed/28962456
http://dx.doi.org/10.1016/j.toxrep.2015.08.001
work_keys_str_mv AT elgawishraniaabdelrahman greenteaextractattenuatesccl4inducedhepaticinjuryinmalehamstersviainhibitionoflipidperoxidationandp53mediatedapoptosis
AT rahmanhaidygabdel greenteaextractattenuatesccl4inducedhepaticinjuryinmalehamstersviainhibitionoflipidperoxidationandp53mediatedapoptosis
AT abdelrazekhebama greenteaextractattenuatesccl4inducedhepaticinjuryinmalehamstersviainhibitionoflipidperoxidationandp53mediatedapoptosis