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Phenolic excipients of insulin formulations induce cell death, pro-inflammatory signaling and MCP-1 release

Skin reactions at the infusion site are a common side effect of continuous subcutaneous insulin infusion therapy. We hypothesized that local skin complications are caused by components of commercial insulin formulations that contain phenol or m-cresol as excipients. The toxic potential of insulin so...

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Detalles Bibliográficos
Autores principales:	Weber, Claudia, Kammerer, Daniel, Streit, Bettina, Licht, Alexander H.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2014
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5598374/ https://www.ncbi.nlm.nih.gov/pubmed/28962351 http://dx.doi.org/10.1016/j.toxrep.2014.11.019

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