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A peripherally restricted P2Y(12) receptor antagonist altered rat tumor incidences with no human relevance: Mode of action consistent with dopamine agonism
BACKGROUND: Ticagrelor is an orally available, direct acting and reversible P2Y(12) receptor antagonist approved for treatment of acute coronary syndrome. The objectives of these studies were to (1) evaluate the Ticagrelor 2-year rat carcinogenicity bioassay data; (2) investigate potential mode of a...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5598522/ https://www.ncbi.nlm.nih.gov/pubmed/28962330 http://dx.doi.org/10.1016/j.toxrep.2014.11.010 |