Structure of 7-hy­droxy-3-(2-meth­oxy­phen­yl)-2-tri­fluoro­meth­yl-4H-chromen-4-one

Herein, the synthesis and crystal structure of 7-hy­droxy-3-(2-meth­oxy­phen­yl)-2-tri­fluoro­meth­yl-4H-chromen-4-one, C(17)H(11)F(3)O(4), are reported. This isoflavone is used as a starting material in the preparation an array of potent and competitive FPR antagonists. The pyran ring significantly...

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Detalles Bibliográficos
Autores principales: Low, John Nicolson, Gomes, Ligia R., Gaspar, Alexandra, Borges, Fernanda
Formato: Online Artículo Texto
Lenguaje:English
Publicado: International Union of Crystallography 2017
Materias:
Research Communications
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5598833/
https://www.ncbi.nlm.nih.gov/pubmed/28932421
http://dx.doi.org/10.1107/S2056989017009896
Descripción
Sumario:Herein, the synthesis and crystal structure of 7-hy­droxy-3-(2-meth­oxy­phen­yl)-2-tri­fluoro­meth­yl-4H-chromen-4-one, C(17)H(11)F(3)O(4), are reported. This isoflavone is used as a starting material in the preparation an array of potent and competitive FPR antagonists. The pyran ring significantly deviates from planarity and the dihedral angle between the benzo­pyran mean plane and that of the exocyclic benzene ring is 88.18 (4)°. In the crystal, O—H⋯O hydrogen bonds connect the mol­ecules into C(8) chains propagating in the [010] direction.

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